Expression And Significance Of Survivin And Bcl-2 In Condyloma Acuminatum

Objective To investigate the expression of Survivin and its relationship with the expression of B-cell lymphoma / leukemia-2(Bcl-2) in condyloma acuminatum(CA).Method Immunohistochemical S-P method was employed to detect the expression of Survivin and Bcl-2 in 60 cases of CA and 10 cases of prepuce of mature men. To calculate the percentage of positive cells under the microscopic examination.All of analyses were performed by SPSS11.5 software package. P<0.05 was considered statistically significant in all tests.Result Survivin was expressed in 52 of 60(86.67%)cases of CA and 2 of 10(20%) cases of normal prepuce tissues.Expression of Survivin was significantly higher in CA than in normal prepuce tissues( P<0.01).It was different for positive rate of Survivin in every layer in CA.The positive rate in stratum spinosum was 95.00%,which was higher than 80.88% in basal layer and 78.33%in stratum granulosum( P<0.05). But no difference could be found between basal layer and stratum granulosum.In normal prepuce tissues,positive cells were mostly distributed in basal layer.The positive rate of Bcl-2 in CA is 66.67%,while there is no expression of Bcl-2 in normal prepuce tissues.Expression of Survivin was positively related to expression of Bcl-2( P<0.01). Conclusion Survivin may play an important role in the pathway of development of CA and it may be identified as a new therapeutic target.Anti-apoptosis related gene Bcl-2 may have a synergic role with survivin in the development of CA.These may expand a new diea of therapeutic alliance with the treatment of CA.