Initial Study On The Effects Of Human Cytomegalovirus Infection On Endometrial Receptivity During Peri-implantation Period

Objective: Through clinical case control study, to initially investigate the effect of human cytomegalovirus infection on the endometrial receptivity formation during the window of implantation and the probable mechanism of action, to provide the prophase theoretical documents for hunting the new adverse factors affecting the embryo implantation.Methods: Collect the endometrial samples of child-bearing period women with active infection of HCMV, inactive infection and non-infection of HCMV during the peri-implantation period. Immunohistochemical staining was used to determine the expression of estrogen receptor, progesterone receptor and integrinβ3 subunit in endometrial epithelial cells.Results: Compared with the other two groups, a significantly lowerβ3 integrin expression was observed in glandular epithelial cells of endometrial biopsies from active infected women(P均<0.05),at the same time,β3 integrin was mainly stained in the plasma of glandular epithelial cells in 8 endometrial biopsies samples. There was no difference in the expression ofβ3 integrin between the inactive infected group and non-infected group(P>0.05). There was no difference in the expression of estrogen receptor and progesterone receptor among the three groups(P>0.05).Conclusion: 1.The active infection of HCMV produces reductive expression ofβ3 integrin in glandular epithelial cells of endometrium, and then disturbes the building of endometrial receptivity during peri-implantation period.2. The mechanisms of reductive expression ofβ3 integrin was concerned with the internalization of the receptors,when HCMV glycoproteins gH bind to integrinαvβ3.