The Clinical Features And Correlation Analysis Of Active Human Cytomegalovirus Infections In Patients With Ischemic Cerebrovascular Diseases

Objective:It is well known that artherosclerosis(AS) is the most common cause for ischemic cerebrovascular diseases(ICVD) . Cerebrovascular diseases are of the most harmful human diseases with highest morbidity,characteristic of atherosclerosis.Recently,there is growing evidence indicates that infection and recurrent activation of herpes virus are likely to be its fundamental cause and trigger,especially human cytomegalovirus(HCMV). The aim of this study is to discuss the correlation between activation of HCMV and ICVD by Case-control study, and to analyse epidemic characteristics of activate HCMV infections in patients with ICVD.Methods:Clinical data 392 cases of locally ICVD from January 2002 to December 2008 were retrospectively analyzed(includes 290 patients with cerebral infarction (CI) and 102 patients with transient ischemic attack(TIA) ), compared with 290 normal persons as control concurrently. A 1:1 matched case-control study method was adopted between TIA and control group, CI and control group,young ICVD and control group respectively,and we selected risk factors of ICVD by logistic regression model, summarized epidemic characteristics and seasonal features of activation of HCMV in 261 patients with ICVD.Results:1. To compare risk factors of CVD between TIA group and control group, we drew a conclusion by single factor analysis . The results indicated that five factors which were hypertension, hyperlipidemia (HLP), diabetes, active HCMV, formation of atherosclerotic plaque were higher than the contrast group with the notable difference by statistics(P<0.01). After Logistic regression, three factors which were hypertension(OR=1.788), active HCMV (OR=3.641), formation of atherosclerotic plaque (OR=11.020) entered regression equation eventually .2. To compare risk factors of CVD between CI group and control group, we drew a conclusion by single factor analysis. The results indicated that four factors which were hypertension,HLP,active HCMV, formation of athero- sclerotic plaque were higher than the contrast group with the notable difference by statistics(P<0.01),diabetes was higher than control group (P<0.05). After Logistic regression, three factors which were hypertension (OR=2.237), active HCMV(OR=2.250), formation of atherosclerotic plaque (OR=6.215) entered regression equation eventually .3. To compare risk factors of CVD between young CVD group(15-45 years old age) and control group, we drew a conclusion by single factor analysis. The results indicated that three factors which were hypertension, active HCMV, formation of atherosclerotic plaque were higher than the contrast group with the notable difference by statistics(P<0.01), Coronary heart disease(CHD) was higher than control group(P<0.05). After Logistic regression, three factors which were hypertension (OR=1.562), CHD (OR=2.103), formation of atherosclerotic plaque (OR=2.014) entered regression equation eventually .4. Single factor analysis was performed for the related factors in HCMV actively infectious patients with ICVD.As for genetic factors , HLP and smoking , there was great significant difference between the groups of HCMV positive and negative(P<0.01). And as far as TIA was concerned , group of HCMV positive was higher than negative group(P<0.05).5.we also observed seasonal features in patients with ICVD which were diagnosed as HCMV positive.After X2 test, there was no difference in seasonable distribution of HCMV active infection . The infection rate in spring and summer was bit more than the other seasons'.Conclusions:There is high incidence of active HCMV in patients with ICVD,and HCMV stimulates and plays an important role in the developmant and progression of AS. It may be an independent risk factor for ICVD . there seems to be epidemic character and seasonal features of HCMV in patients with ICVD,but more samples need to be observed and further research to be performed.