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The Relationship Between LVEDd Left Ventricular Function And Ventricular Arrhythmia In Ischemic Cardiomyopathy

Posted on:2009-04-03Degree:MasterType:Thesis
Country:ChinaCandidate:T ChuFull Text:PDF
GTID:2144360242480323Subject:Internal Medicine
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Ischemic cardiomyopathy(ICM)is one of 5 clinical categories in coronary artery disease. It was described by Raftery in 1969 as a series of clinical syndromes like dialated cardiomyopathy caused by coronary atherosclerosis. It was named ICM by Burch in 1970 and then generally acknowledged.In the past decade, ICM was a tough problem which was widely investigated by cardiovascular specialists all over the world. The live time of these patients is shorter than those who suffer non-ischemia heart failure and the therapeutic efficacy is worse .besides, 70%~80% of these patients can suffer various kinds of arrhythmias, of which ventricular arrhythmias,atrial fibrillation and conduction block are common,and these arrhythmias may lead to cardiogenic sudden death. The patients'survival rate, whose LVEF≤0.35~0.4,is 35%~60%. So it is important to investigate the relationship between cardiac dilatation, cardiac function and ventricular arrhythmias.In this article,data of 120 ICM patients were collected in the third affiliated hospital of Jilin University during 2004 to 2008 . The data contain patient history,physical examination,chest X-ray,color Doppler and electrocardiogram(ECG).In 120 patients, who were diagnosed according to Burch (1972) diagnostic criteria,there are 70 males and 50 females(1.4:1)and the average age is 66.34±10.27.According to the heart function,120 patients are graded into two groups: the group with heart failure and the group without heart failure. The former are the patients whose NYHA cardiac functional grading II~IV, left ventricular ejection fraction (LVEF)<50%,left ventricular fractional shortening(LVFS) < 25%, this group include 80 patients, male 45,female 35,the average age is 65.13±4.56;The later are the patients whose NYHA cardiac functional grading I, LVEF≥50%, LVFS≥25%, this group include 40 patients,male 25,female 15,the average age is 66.56±6.12. The difference of gender and age between the two groups is not conspicuous(P>0.05).According to left ventricular end-diastolic dimension (LVEDd), 120 patients are graded into two groups: the group with LVEDd≤65mm and the group with LVEDd>65mm. the former group include 45 patients,male 30,female 15,the average age is 66.16±7.09;the later group include 75 patients,male 45,female 30,the average age is 63.83±5.96. The difference of gender and age between the two groups is not conspicuous(P>0.05).All the selected patients do not include acute myocardial infarction within a week,ICM with hypertension,the selected patients'K+,Na+,Ca2+,Cl- are normal and they do not take anti-arrhythmias drugs or install artificial pacemaker. All the selected patients take the examination of ECG or dynamic electrocardiogram(DCG). According to the Hasmmill classification method,premature ventricualr contraction(VPC) is classified into simple type and complex type.The data are analyzed with SPSS10.0 statistical package,examed by chi-square criterion,P<0.05 is the size of the test. Of all the 120 selected patients,57 cases(47.5%)with ventricular arrhythmias,24 cases(20.0%) with simple type ventricular arrhythmias,33 cases(27.5%) with complex type ventricular arrhythmias,17 cases (14.2%) with intraventricular conduction block,15 cases(12.5%)with VPC conbined with intraventricular conduction block.Conclusion: the occurance of complex type ventricular arrhythmias,intraventricular conduction block and VPC conbined with intraventricular conduction block are related to LVEDd;the occurance of complex type ventricular arrhythmias are related to left heart function. We can control the incidence of ventricular arrhythmias by intervening Ventricular Remodeling and improving heart function of ICM, accordingly elevate the patients'survival rate and the quality of life.
Keywords/Search Tags:Cardiomyopathy
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