| Depression is the main type of affective mental disorder. It is often display with decreased food appetite and insomnia, fatigue, psychomotor retardation, anxiety, guiltiness, nonsense, and even has suicidal tendency. which influence patients` working, studying and living seriously. With acute social competition and fasting working rhythm, more people feel mental strain, tiredness, morosity, and attack rate of depressive disorder increasing year by year. Now, depressive disorder has becoming the common ailment and frequently encountered disease in society. Gradually, people take depressive disorder seriously, and more and more medicines appear, but most western medicines which have larger side effect are applied in clinical aspect. However, Chinese traditional medical had known depression 2000 years ago, and had genealogical method to treat it. With the development of science, it is accepted that traditional Chinese medicine has little adverse reaction and precisely therapeutic effect. So it is important to study and research.SGJYY is a Chinese traditional medical prescription derived from the well known"Shugan powder"and"Xiaoyao powder". It could relieve the liver pen, safeguard stomach against damages and soothe the nerve. SGJYY has been widely used in the clinical treatment of depression, and achieved excellent effect. The symptoms of depression patient treated with SGJYY, such as depression, anxiety, insomnia were ameliorated remarkably.In this study, all the mice were used to establish the model depression by separate feeding and long-time chronic unpredictable moderate intensity stimulation(including abrosia, swaming in ice water, clamping tail, lightning stroke footplate, constraint, day and night). During this process, compared with model health, model depression displaying that body weight increasing slowly, depressed, and anepithymia Open-field experiment display that the scores of horizontal and vertical movement were also less than the mice in healthy control group. These results demonstrated that the depression model mice had been established successfully.After depression model being established (each group being given long-time chronic unpredictable moderate intensity stimulation,except common group), giving each depression model mice isodose isotonic Na chloride, Fluoxetine, low dose of SGJYY and large dose of SGJYY by intragastric administration for 21 days. The experiment proves that Fluoxetine was used as a positive control medicine. SGJYY produced a significant improve in rat weight(p<0.05 or p<0.01), horizontal movement (P<0.01), vertical movement(P<0.01 or P<0.001), the consumption of 1% sucrose solution (P<0.05 or p<0.01). The experiment proves that all the groups of SGJYY have therapeutical effect and the big dosage group shows the outstanding effect. At the same time, there is no obvious difference between the SGJYY groups and the Fluoxetine group. The results show that SGJYY has antidepressant-like effect.After the administration ,the rats were sacrificed. Then the blood was obtained by cardiac puncture to demesh the blood-serum. The contents of the Col and ED in the blood-serum were determined by RI. The result showed that,â‘ comparing with the model group, the content of the Col in the blood-serum of the SGJYY large and low dose group, the discrepancies all have significance (P<0.01). That is hint that SGJYY may rival the hyperfunction state of the HPAA of the depression model rats to play a part in anti- depression.â‘¡comparing with the model group, the content of the ED in the blood-serum of the SGJYY large and low dose group, the discrepancies all have significance (P<0.01). That is hint that SGJYY may raise the insufficiency of function state of the HPGA of the depression model rats to play a part in anti-depression. The manifestation of the result that from the two aspects supports the theory of HPAA hyperfunction and HPGA insufficiency of function in the neuroendocrine hypothesis that reported in the literature. But the dependability of HPAA and HPGA needs penetrating research.In summary, this experimental result show that, SGJYY can improve the depressionof the depression rat, and cut down the content of the Col in the blood-serum that hadbeen elevated, and can heighten the content of the ED in the blood-serum that had been rdg. The result also hint that, the anti-depression mechanism of action of SGJYY may concerned with regulating HPAA and HPGA functional disorder. This study supply rationale for SGJYY in the therapy of depressive disorder in clinical. |
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