| Objective To study the expression of Pokemon protein and PCNA in different gastric mucosa and its clinical significant in gastric carcinoma and atypic hyperplasia of gastric mucosa. Methods Gastric carcinoma (N=87), atypic hyperplasia gastric mucosa (N=43), normal gastric mucosa (N=20) were analyzed for Pokemon and PCNA expression by immunohistochenistry and tissue microarray using specific antibody.Results Pokemon protein expression and PCNA expression was high in 71 of 87 cases in gastric carcinoma, which was significantly different from the expression in normal gastric mucosa and atypic hyperplasia of gastric mucosa, in atypic hyperplasia of gastric mucosa, expression of Pokemon and PCNA was relative to high and low of hyperplasia of gastric mucosa. It was highly expressed in gastric carcinoma and was highly relation with liver transformation. Conclusion Pokemon protein expression and PCNA expression correlation with the carcinogenesis of gastric carcinoma .maybe, It correlate with the carcinogenesis and progression of atypic hyperplasia of gastric mucosa, gastric carcinoma.
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