An Analysis On Risk Factors Of Postoperative Nausea And Vomiting

Objective To evaluated the potential risk factors of post-operative nausea and vomiting(PONV) in adult patients,offering the theory for clinical prevention and treatment.Methods Univariare and multivariate analyses of clinical factors associated with PONV were undertaken in a retrospective case-control series of 167 adult patients undergoing gynecological laparoscopic surgery under general anaesthesia. We examined PONV for the first 2h and 24h. Factors examined were age, body mass index (BMI), type of general anaesthesia (sevoflurane and fentanyl or royal intravenous (i.v.) anaesthesia with propofiil and fenranyl), duration of surgery, ASA physical status, a history of PONV or motion sickness and intraoperarive fentanyl dose.A logistic model was developed to evaluate predictors of PONV.Result 78 patients (44.91%) reported one or more episodes of PONV during the study period. Duration of surgery(P <0.01), a history of PONV or motion sickness(P <0.01)and general anaesthesia with inhalational anaesthetics (P <0.01)were significantly related to nausea and vomiting during 24h postoperatively. Othher factors, including age,BMI,ASA physical status and intraoperarive fentanyl dose did not alter the risk for nausea and vomiting. Conclusion We conclude that a history of PONV or motion sickness, duration of surgery and general anaesthesia with inhalational anaesthetics are the main risk factors for PONV after gynecological laparoscopic surgery in adults. Age,BMI,ASA physical status and intraoperarive fentanyl dose did not alter the incidence of PONV in our patients.