| Objectives: To understand current situation and epidemic features of HBV among residents in Suzhou, as well as the inoculation status of Hepatitis B vaccines in different areas and people in Suzhou; To evaluate the effect of implementation of Hepatitis B vaccines adding to the children's immunization program, so as to provide scientific basis for the government to make measures to prevent Hepatitis B further.Methods: (1)Sampling Method:Apply multilevel and random sampling method. Take one district from the seven districts of Suzhou as the city investigation base, and one county (city) from the five counties (city) of Suzhou as the country investigation base; take three streets of the sampling district and two towns of the sampling county, then take one resident committee and one Villagers Committee of each selected street and town as the investigation scene. Set the age box of 1~4, 5~14 and 15~59 and use village, individual and family as the unit in the investigation scene to draw sufficient samples.(2)Survey Method:Send out a questionnaire survey to every respondent, and collect their venous blood, segment the serum and keep it under low temperature to examine related index.(3)Examining Method:Use ELISA to inspect the HBsAg, HbsAb and HBcAb. The inspection is undertaken in the Virus Research Department of Chinese Centers for Disease Control and Prevention. The inspection reagent ELISA is produced by InTec Products, Inc in Xiamen(.4)Statistical Method:Input all the material into the EpiData3.1database, and use SPSS11.5 to make statistical processing and analyzing.Results: (1)Demology Features:The respondents vary from area, age, sex, education level, occupation and marriage, etc, among which the ratio between people from city and county is 1:1.01;the constitution of people's age of 1~4, 5~14 and 25~59 people is 19.23%,29.75% and 51.02%;the ratio between male and female is 1:1.06.(2)Inoculation of hepatitis B vaccines:The average hepatitis B vaccine inoculation rate of the Suzhou citizens is 50.64%. There is no distinctive difference in the hepatitis B vaccine inoculation between people in the city and country, while the inoculation rate of the children under 15 years old(75.58%) is clearly higher than young people and adults above 15 years old(26.71%).(3)Epidemic Serology Features as the sign of HBV infection: The rate of HBsAg Positive, HBsAb, HBcAb and HBV infection of the respondents is 5.45%(72/1321), 58.29%(770/1321), 23.69%(313/1321)and 39.89%(527/1321)respectively. There is no distinctive difference of HBsAg Positive Rate between people from the city and country. The HBsAg Positive Rate of children under 15 years old is obviously lower than that of young people and adults above the age of 15, among which children from age of 1~4 is higher than those age of 5~14. The HBsAg Positive Rate of male is higher than that of female, while there is no distinctive difference between male and female under 15 years old.Conclusion: Suzhou has significantly reduced the HBsAg incidence rate and HBV infection rate by Hepatitis B vaccines implemented in the children's immunization program, leading to the change of suzhou from a high epidemic area to a middle one(8%> HBsAg Positive Rate≥2%). With the Hepatitis B vaccines added to the children's immunization program in 1992, the incidence of HBsAg Positive Rate among children under 15 years old has dropped largely, especially much larger among children under 5 years old, which primarily achieves the goal set by WHO West Pacific Area that HBsAg Positive Rate should be controlled under 1%, while the change of HBsAg Positive Rate among the children and adults above 15 years old is not notable.This proves that inoculating Hepatitis B vaccines in big scale is the most effective way to control HBV infection, and suggest that inoculation should be increased in adults, as well as strengthen the implementation in the people in the immunization program.
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