Analysis Of Etiology And Risk Factors In 268 Young Adults' Stroke

Objective:To investigate the possible etiology factors and risk factors in young adult stroke.Methods:268 young patients with stroke were studied in department of neurology of the Second Affiliated Hospital of Dalian Medical University from October 1999 to January 2008. All patients were matched with diagnosis by clinical standards referred to the fourth national cerebrovascular diseases meeting in 1995 and they were confirmed diagnoses by computerized tomography (CT) or magnetic resonance imaging (MRI), excluding the traumatic cerebral hemorrhage and serious liver or renal disease.General parameters were studied, including sex, age, blood pressure, history of past illness, family medical history, smoking,drinking, clinical feature and neuroimaging feature. Laboratory parameters were studied, including blood routine,fasting blood glucose, blood-lidpoids, hemorheolegy and fibrinogen .According to the clinical demand,the part of the patients were examined cordis color hypersound Doppler,cerebrospinal fluid or angiography. To observe the distribution of etiology factors and risk factors in these adults'stroke.Results:1.The young adult group comprised 9.92%(268/2701)of patients of all ages admitted for stroke.179 of 268(66.79%) acute young adults stroke patients were male.89 of 268(38.89%) acute young adults stroke patients were female. The age of onset was 18~45 years old and the mean age was36.05±7.81 years old. 200(75.37%)young patients had definite etiological factor.2.129 of 268(48.13%)were due to ischemic stroke,101(78.29%)young patients had definite etiological factors,including atherosclerosis 65 cases(50.38%),cardiogenic cerebral embolism 18 cases(13.95%) ,hemopathic disease or abnormality of clotting mechanism 4 cases(3.10%),other etiological factors (such as vasculitis etc)14cases(10.85%).3.139 of 268 were due to hemorrhagic stroke,99(71.22%)young patients had definite etiological factors,including hypertension53 cases(38.12%),intracranial blood vessel dysplasia(aneurysms,arteriovenous malformations,Moyamoya disease,cavernous angioma,dural arteriovenous fistulae)37 cases(26.62%),other etiological factors (such as intracranial tumors etc)9 cases (6.48%).4.In young adults with stroke,44 of 268(16.41%) had history of TIA or cerebral stroke;19 of 268(7.08%) had family history of cerebral stroke, 2 of 268 (0.74%) had history of oral contraceptive medication,50 of 268(27.28%) had history of smoking,45 of 268 (25%) had history of drinking, after the patients were admitted to hospital, according to the auxiliary examination, this article finded that 120 of 268 (44.77%) suffered from hypertension, 85 of 268 (31.71%) suffered from hyperlipemia,34 of 268 (12.68%)suffered from cardiac disease,14 of 268 (5.23%) suffered from diabetes mellitus.Conclusions:1.The incidence of stroke of the young adults has the increasing trend year by year, and increase with growth of the age. hemorrhagic stroke in young adults is higher and male predominance existed the percentage of stroke in young adults is higher.2.The main etiological factor of ischemic cerebral stroke in young adults is still atherosclerosis, cardiogenic cerebral embolism is followed, other etiological factors(such as vasculitis,Moyamoya disease) are few, about one fourth patients have no definite etiological factor.3.The main risk factors of cerebral stroke in young adults are hypertension,hyperlipemia,smoking,drinking,history of TIA or stroke,family history of stroke and so on.4.It will has great significance to control or delay incident onset if we can prevent and treat these risk factors of young stroke efficiently.