Abnormalities During The Resting State Functional Magnetic Resonance Imaging In Treatment-naive Major Depression Disorder And First-degree Relatives

Objective:We explored differences of brain spontaneous activity in resting state between depression, degree-first relative and controls using function magnetic resonance imaging (fMRI) in order to find the base of neural activity in depression associated with phathophysiological mechanism.Method:15 subjects with depression, 15 degree-first relatives and 15 sex, age and education-matched controls underwent 3 min and 40 sec fMRI scans while resting state. ReHo and Alff analysis were used to detect neural spontaneous activity across the whole brain by REST. Two within-group analysis was performed among three groupes by t-test (p<0.005) by SPM2.Result:1.subjects :there were no significant differents among MDD, fierst degree relative as well as control respect to age and gender as well as education .2. fMRI results2.1 depression patients and controls2.1.1 ReHo analysis:The ReHo of right insula, right lentiform nucleus, left cerebellum, left middle frontal gyrus,left superior temporal gyrus,left precentral gyrus (frontal lobe), left postcentral gyrus (parietal lobe), left parahippocampal gyrus, left thalamus were significantly decreased in resting state in depression compared to control;2.1.2 Alff analysis:The Alff of left precentral gyrus (frontal lobe),left postcentral gyrus (parietal lobe),left parahippocampal gyrus,left cerebellum were significantly decreased in resting state in depression compared to controls.2.2 first-degree relatives and controls2.2.1 ReHo analysis: the ReHo of right insula, anterior lobe and posterior lobe of left cerebellum, left parahippocampal gyrus were decreased in resting state in first-degree relatives compared to controls ;2.2.2 Alff analysis: the Alff of left middle frontal gyrus, left precentral gyrus (frontal lobe) were decreased in resting state in first-degree relatives compared to controls .2.3 depression patients and first-degree relatives 2.3.1 ReHo analysis: the ReHo of left precentral gyrus (frontal lobe ),right anterior cingulate,right lentiform nucleus were decreased in resting state in depression compared to first-degree relative;2.3.2 Alff analysis: the Alff of left cerebellum,left anterior cingulate, left thalamus were decreased in resting state in depression compared to first-degree relative;Conclusion:1.Compared to controls,the depressed patients and first-degree relatives all showed the decreased ReHo in right insula, left cerebellum, left parahippocampal gyrus,which implicated the decreased regional homogeneity of these regions may be the trait mark in depression;2. Compared to controls,the depressed patients and first-degree relatives all showed the decreased Alff in left precentral gyrus (frontal lobe), left postcentral gyrus (parietal lobe),which implicated the decreased amplitude of regional activity in these regions may be the trait mark in depression;3. Compared to controls,the depressed patients showed the decreased both ReHo and Alff in left precentral gyrus (frontal lobe),left postcentral gyrus (parietal lobe), left parahippocampal gyrus, left cerebellum.the present result implicate that these regions play a importance role in mechanism of pathophysiology in depression.