Clinical Study Of Intrapleural Injection Of Lentinan, IL-2 And IFN-γ Combined With Metronomic Chemotherapy In The Treatment Of Malignant Pleural Effusion

Objective:To observe the therapeutic efficacy of intrapleural injection of lentinan, IL-2 and IFN-γcombined with metronomic chemotherapy in the treatment of malignant pleural effusion.Methods:16 patients with malignant pleural effusion were given intrapleural injection of lentinan,IL-2 and IFN-γthrough central venous catheter for 3 weeks. At the same time,give them metronomic chemotherapy by taking low-dose of compound cyclophosphamide and compound tegafur.Evaluate the efficiency and the patients' quality of life.Results:The effective ratio of cases who received intrapleural injection of lentinan,IL-2 and IFN-γcombined with metronomic chemotherapy comes to 100%, and the CR ratio comes to 75%.And all patients improved their quality of life significantly.Conclusion:The effect of intrapleural injection of lentinan,IL-2 and IFN-γcombined with metronomic chemotherapy is significant in the treatment malignant pleural effusion.And it may be one useful method in clinic.