Significance And Effects Of Serum Ischemia Modified Albumin On Percutaneous Coronary Intervention

Objective: Percutaneous coronary intervention(PCI), a technique of revascularization of coronary vessel, has been extensively used to treat coronary heart disease (CHD). In the course of PCI, it can be occured that minor damage of the myocardiac because of the collateral occlusion, transient coronary spasm, coronary microembolization or intensity of procedure itself. Ischemia modified albumin (IMA) is a new biochemical marker, which appears earlier than cardiac troponin I(cTnI) and creatine kinase-MB (CK-MB), So it can be used to detect the myocardial injury. The aim of the study is to explore the changes of the concentrations of IMA in serum with the CHD patients underwent PCI and its the clinical significance.Methods: Determining the serum levels of IMA and cTnI in 60 patients undergoing PCI and 60 patients undergoing coronary artery angiography(CAG). In all patients, blood samples were collected for determining IMA before operation, and 0.5, 4, 12 hours after operation. In all patients, blood samples were obtained for determining cTnI before operation and 4, 12hours after operation. Furthmore the pressure of inflation, duration of inflation and number of times of inflation were recorded during PCI. Resoult: The levels of IMA in all patients of PCI group were significantly increased at 0.5hours after operation (p<0.01), and began to decreased at 4 hours and returned to the baseline at 12 hours(p>0.05) after PCI; the levels of cTnI in 34 patients were increased at 12 hours after PCI(p<0.05), and others had no any changes before and after PCI. In control group, the levels of IMA and cTnI levels remained unchanged before and after angiography(p>0.05). The levels of IMA and cTnI in serum showed were correlation with the total pressure of inflation, total number of times of inflation, total of duration of inflation.Conclusion: The concentrations of IMA, which appears earlier than cTnI, were significantly increased after PCI and are related to the pressure, duration and number of times of inflation. So the levels of IMA is not only a biochemical marker of early diagnosis of myocardial ischemia, but also an indicator of severity of myocardial ischemia.