The Effect Of Statin Intensive Treatment On The Levels Of Ischemia Modified Albumin In Patients With Unstable Angina Pectoris Undergoing Percutaneous Coronary Intervention

BackgroundCoronary heart disease (coronary heart diseases, CHD) is the group ofdiseases that cause serious damage to human health, unstable angina（unstableangina, UA) is one of the most common type of coronary heart disease. With therising morbidity of coronary heart disease (CHD), the application of percutaneouscoronary intervention(PCI) is also growing popularity at home and abroad, but themyocardial injury caused by the PCI is still an important issue at present. Statinshas become a routine treatment approaches for patients with coronary heart diseaseand PCI because of its effective lipid modulation and pleiotropy. A series of recenttrials show that short-term strengthened statins therapy before PCI can reducepostoperative inflammatory response and offer effective protection to myocardialinjuries caused by PCI. Recent years,ischemia modified albumin (IMA) as a newmarker for early myocardial ischemia, is drawing attention from China and abroad.The previous literature reported that IMA is the most sensitive biochemical markerfor myocardial ischemia diagnosis, because it has high sensitivity、 high negative predicted values、narrow time windows and so on. Furthermore, it can increaseafter the PCI operation that causes short-term myocardial injury. However, there arefew reports about this in China and almost no literature about the effect of statinsintensive treatment on the levels of ischemia modified albumin (IMA) in patientswith unstable angina pectoris undergoing percutaneous coronary intervention (PCI).ObjectionTo explore the effect of statin intensive treatment on the levels of ischemiamodified albumin (IMA) in patients with unstable angina pectoris undergoingpercutaneous coronary intervention (PCI).MethodsSeventy patients with unstable angina pectoris undergoing elective PCIsurgery, were randomly divided into intensive treatment group of35cases (12hours before surgery to give atorvastatin80mg) and conventional treatment groupof35cases (12hours before surgery not administered) for the study.The twogroups blood were collected before and after surgery,30min,6h and24h, thedetection level of IMA, simultaneous detection of cTnI, CK-MB levels werecompared.Results1．The levels of IMA, cTnI, CK-MB were not significantly different betweenthe two groups before PCI (P>0.05);2．Levels of IMA began to increase30min after PCI, and gradually decreased tobaseline levels6h after PCI, while cTnI, CK-MB only began to rise6h after PCI,and still in peak level24h after PCI;3．The elevated extent of each index after PCI in intensive therapy group waslower than the conventional treatment group, the difference was statisticallysignificant (P <0.05). Conclusions1．Levels of IMA began to increase30min after PCI, earlier than the rise ofcTnI and CK-MB,IMA can help to early diagnosis of acute myocardial ischemia;2．Statins intensive therapy before PCI can reduce the increase levels ofpostoperative IMA、cTnI、CK-MB in patients with unstable angina pectoris, andoffer effective protection to acute myocardial injury caused by PCI;3．For the UA patients who have accepted regular statins treatment, givingatorvastatin80mg once more to them12h before PCI has good security.