| Objects1 To find a new index to detect the renal function after renal transplantation. This index was used in detecting the graft function. Meanwhile we rearch the relationship between Cystatin C and GFR (glomerular filtration rate).2Through compared with Scr and BUN, to show the vulue of Cystatin C as an index in detecting the graft function after renal transplantation. And the value of cystatin C (Cys C) in the early detection of the graft function damagement after renal transplantation and providing evidence for the further diagnosis and treatment.MethodologyAt the twelfth day post-transplantation, monitored the concentration ofCys C, blood urea nitrogen (BUN) , Serum creatinine (SCr) and the glomerular filtration rate (GFR). GFR was determined by the Modification of Diet in Renal Disease equation (MDRD equation). According to the value of GFR post-transplantation, 70 cases of renal transplant patients were divided into group A (31 cases, with the normal renal function, GFR=90ml/min/1.73m~2), group B (Scr=133μmol/L, 60=GFR<90ml/min/1.73m~2, 27 cases), group C (Scr > 133μmol/L, 60=GFR<90ml/min/1.73m~2,12 cases) and group D (GFR < 60ml/min/1.73m~2, 4 cases). Meanwhile, the normal control group (n = 60) was compared. Analysis the linear correlation between Cys C, Scr and GFR through the scatterplots in each groups, and calculated the correlation coefficient(r). Determination of Cys C was performed using the Behring BN II Pro Spec analyzer. Meanwhile, used the automatic biochemistry analyzer and correlated kits to analysis the serum creatinine concentration.Results1. Cys C concentration in normal control group was 0.72±0.13 mg/L. Scr concentration was 50.48±15.20μmol/L.2. The concentration of Scr, Cystatin C and BUN had no conspicuous statistically significance (P>0.05), compared with the normal control pre-transplantation.3. Cys C concentration in group B (27 cases) were (1.37±0.14), the difference has conspicuous statistically significance (P<0.01), compared with that of group A (0.96±0.10) mg/L.4.Scr concentration in group B (27 cases) were (105.26±13.76)μmol/L, the difference has no statistically significance (P>0.05), compared with that of group A (90.51±9.86)μmol/L.5.Through the scatterplot, SCr and Cys C showed similar linear correlation with GFR in group A, B and C. The correlation coefficient (r) of each group was -0.7272 and -0.7439, -0.7072 and -0.7543, -0.7430 and -0.7669.ConclusionCys C concentration was not influenced by diet, infection. Compared with the Scr, Cys C has the similar relevance with GFR even better when the graft function was normal and lightly renal function damaged. After transplantation, when the grafts function was damaged slightly, the Cys C had a more sensitive changement, espiacially when the Scr concentration had not increased. This indicated that the Cys C had a more sensitively and intimate correlation with GFR. Cys C, as a rapid, sensitive index, could be used in the early diagnosis of renal function damage after renal transplantation.SignificanceOur study is useful for renal transplantation in order to enhance long-term survival. It can diagnose early damagement of the draft function and help doctors to adjust the dose of immunosuppressant.
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