| Diabetes mellitus(DM)is a more complex metabolic disorders related to heredity and the environment,the incidence rate in the crowd is increasing year by year,of which 90 percent of non-insulin-dependent diabetes mellitus(NIDDM),also known as type 2 diabetes mellitus.The pathogenesis of Type 2 diabetes mellitus has not yet been fully clarified, the prevailing view is that insulin resistance(IR)and beta cell dysfunction are two important areas of the development of the diabetes mellitus.So to improve the body insulin resistance and the beta cell secretion are the main treatment of type 2 diabetes mellitus.The study in type 2 diabetes mellitus in high-risk groups,since the NGT to type 2 diabetes mellitus in the process of evolution,there have always been insulin resistance andβ-cell function gradually decline. In the clinical diagnosis of type 2 diabetes mellitus,beta cell function for only about 50 percent of normal;after six years,beta cell insulin secretion will be loss of about 50 percent;most patients will be completely lost after 10 to 15 years.So many domestic and foreign researches are focus on improving insulin resistance and protection of beta cell function of DM patients,rather than a simple blood sugar control. Some research shows that some supplementing qi,Yin,clearing away the heat-evil heat and promoting blood circulation Chinese medicine not only have a certain role in improving insulin resistance,but also to update islet cells,the restoration and protection ofβ-cell function,thereby preventing the occurrence of complications development has a positive role.A study by insulin and(or)increase insulin with supplementing qi and nourishing yin,activating blood circulation and hypoglycemic Chinese medicine treatment of patients with diabetes can haveβ-cell function have significantly restored and improved,but to insulin and Chinese medicine in the treatment of The best effect.Diabetes mellitus belong to the "emaciation-thirst disease" areas of Chinese medicine,the pathological changes of the lines of:before the extreme heat due to deficiency of yin,following the deficiency of both the vital energy and yin,finally,asthenia of both the spleen and the kidney as well as deficiency of both yin and yang.Modern research considered that deficiency of both the vital energy and yin and blood stasis is the main pathogenesis in type 2 diabetes mellitus,it was reported that the incidence of diabetes blood stasis rate of about 60 percent,the treatment should be supplementing qi and nourishing yin, promoting blood circulation by removing blood stasis.Chinese medicine has attached great importance to the islet function in the role of disease. Zhang Xichun Qing Dynasty" medicine zhong zhong can xi lu" attaches great importance to the protection of pancreatic(In this book,he will pancreas as "Cui",is the vice spleen dirty)function in the treatment in the treatment of important diseases Role and set of the famous "Cui Zi drink" for treatment.The Institute used supplementing qi and nourishing yin, promoting blood circulation prescription,is in Zhang Xichun "Cui Zi drink" on the basis of addition and subtraction from the group,to treat type 2 diabetes patients with deficiency of both the vital energy and yin and blood stasis type,by comparing before and after treatment Homa-IR, Homa-βeffects such as indicators of Chinese medicine supplementing qi and nourishing yin,promoting blood circulation in the treatment of type 2 diabetes insulin resistance andβ-cell function may be impaired,to improve the clinical diabetes beta cell dysfunction opened up new avenues.ObjectiveTo reveal the important mechanisms of TCM treatment of diabetes and further explore the unique role of the protection against pancreatic isletβ-cell dysfunction with supplementing qi and nourishing yin and activating blood flow Methods. MethodAccording to 1999 WHO announced the latest diagnostic criteria for diabetes and "Chinese medicine clinical research of new drugs·guiding principles of Chinese medicine clinical research of new drugs diabetes guiding principles"(China Medical Science and Technology Press,2002, 5.The first edition)by the deficiency of both the vital energy and yin and blood stasis syndrome diagnostic criteria,into deficiency of both the vital energy and yin and blood stasis type of patients with type 2 diabetes 60 patients were randomly divided into test group and control group.Both groups were observed before and after treatment about fasting plasma glucose(FPG),2-hour postprandial glucose(2hPG),Fasting insulin (FINS),glycosylatedhemoglobin(HbA1c),to evaluate Chinese medicine supplementing qi and nourishing yin and activating blood flow Methods in the protection of beta cell dysfunction from the possible role.Result1.All of the cases according with the diagnosis of Type 2 Diabetes Mellitus and the deficiency of qi yin and stagnation of blood Syndrome.2.Supplementing qi and nourishing yin and activate blood flow integral blood stasis syndrome patients with severe high blood glucose and insulin levels;treatment group Homa-IR,Homa-βimproved significantly than the control group,there are significant differences.3.After the efficacy of treatment,the test group has significantly higher efficiency than the control group.There is significant difference between these two groups.Conclusion1.The deficiency of qi yin and stagnation of blood Syndrome is one kind of common syndrome in Type 2 Diabetes Mellitus,the stagnation of blood of T2DM observed the always exist.2.The seriousness of deficiency of both the vital energy and yin and blood stasis syndrome are related to the insulin resistance and islet beta cell dysfunction of type 2 diabetes.More severe deficiency of both the vital energy and yin and blood stasis syndrome,the FPG,FINS,Homa-IR and Homa -βindex are higher.3.Supplementing qi and nourishing yin and activating blood flow decoction with hypoglycemic western medicine can significantly improve insulin resistance and islet beta cell dysfunction of type 2 diabetes in deficiency of both the vital energy and yin and blood stasis syndrome. |
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