The Effect Of Supplementing Qi And Nourishing Yin And Promoting Blood Circulation To Dispel Blood Stasis Formula On ADAMTS-1,TGF-β₁ Of The Rat's Myocardium Tissue Induced By CVB_3m Chronically

Objective:To observe the effects the formula of supplementing qiand nourishing yin,promoting blood circulation to dispel blood stasis onthe thecoxB3m induce chronic myocardial injuring the rat'myocardiumtissue ADAMTS-1,TGF-β₁ model with viral cardiomyopathy.To investigateits mechanics,then to provide academic warranties for preventing andcuring the viral myocardial disease early.Methods:Establishing the animal models of the early viral dilatedcardiomyopathy with the method of repeating injecting CVB3m virus to theperitoneal cavity of the Balb/c rats.Deviding the 210 Balb/c rats into fourgroups random.The blank group has 30 rats.The model group,the high dosechinese traditional medicine group and the low dose chinese traditionalmedicine group have 60 rats each.mand,the ultrastructure of the formula ofHE,VG c hromosome dye and the expression of the TNF-α,mRNA in themuscletissue of the heart.To bserve the express of ADAMTS-1 and TGF-β₁in the myocardial tissue with the forual of RT-PCR.Result:1.The formula of supplementing qi and nourishing yin,promotingblood circulation to dispel blood stasis can depress the quality indicatorof the rat model with viral cardiomyopathy.And the effects of the high dosechinese traditional medicine group is the best.2.The formula of supplementing qi and nourishing yin,promotingblood circulation to dispel blood stasis can improve the changes of thepathomorphismand and the ultrastructure of the rat model with viralcardiomyopathy,then to reduce the injury on its myocardial pathology.3.The formula of supplementing qi and nourishing yin,promotingblood circulation to dispel blood stasis can play down the expression of theADAMTS-1 Level of the rat model with viral cardiomyopathy.And theeffects of the high dose chinese traditional medicine group is the best. 4.The formula of supplementing qi and nourishing yin,promotingblood circulation to dispel blood stasis can play down the expression of theTGF-β₁ Level of the rat model with viral cardiomyopathy.And the effects ofthe high dose chinese traditional medicine group is the best.Conclusions:The formula of supplementing qi and nourishing yin,promoting blood circulation to dispel blood stasis can alleviate thepathologic injury,and lowing the expression of myocardial tissueADAMTS-land TGF-β₁.and then to allieviate the bisintigrin resolve outsidethe cells and myocardial restructure.This may be its function mechanism ofits preventing and curing vial myocardial disease.