The Expression And Significance Of ODC In Oral Leukoplakia

Objective: Through analyzes ODC in the oral cavity normal mucous membrane, oral lichen planus, the oral leukoplakia and in the scale cancer clinical pathology organization expresses the masculine gender rate difference to study the relations which ODC and the oral cavity floccosoids pathological change occurs.Methods: Selects the Dalian Medical college attached first hospital oral cavity branch 2006-2007 year pathology department diagnosis 22 example oral leukoplakia is the object of study, with 11 example normal oral cavity mucous membrane organization, 22 example oral lichen planus and 22 example oral scale cancer organizes to make the comparison, carries on the mucous membrane organization the paraffin wax embedding, fixed, the slice, carries on the immunity group dyeing, after the slice makes decent under the microscope the observed result, the semi-quantitative method determines its expression intensity, calculates the cell masculine gender expression percentage, and with counts the software to analyze its statistics difference.Results: In the normal oral cavity mucous membrane, oral lichen planus, the oral leukoplakia and the oral cavity scale cancer organizes the ODC expression to increase in turn; The cancer organizes the ODC masculine expression rate obviously to be higher than the normal oral cavity mucous membrane, oral lichen planus and the oral leukoplakia (p﹤0.05), ODC is higher than the normal oral cavity mucous membrane in the oral lichen planus masculine expression, but does not have statistics difference (p﹥0.05), ODC has the remarkable difference in the oral leukoplakia masculine expression and the normal mucous membrane and oral lichen planus. (p﹤0.05).Conclusions:1.ODC presents the high expression in the oral leukoplakia, its expression's height and the oral leukoplakia epithelial cell's unusual proliferation degree height has the relevance.2.ODC presents the high expression in the oral cavity scale cancer, its expression's height and the scale cancer's malignant degree height has the relevance.3.May judge the oral leukoplakia through the ODC expression to become malignant the tendency as well as the oral cavity scale cancer's malignant degree. ODC may become malignant and the early oral cavity scale cancer's auxiliary diagnosis symbol as the oral leukoplakia.