Perioperative Use Of Antiplatelet Therapy In Coronary Artery Bypass Graft

Coronary artery bypass graft surgery is a effective method in the therapy of coronary heart disease, which can relieve angina, improve improve of myocardium, avoid myocardial infarction, improve quality of life and increase in life span.Antiplatelet therapy is foundation stone to prevent thrombosis in coronary artery bypass graft surgery.And it is very important in keeping Saphenous vein graft patent and preventing cardiovascular accident.Aspirin can inhibits epoxidase nonreversible, through blocks the metabolic pathway of platelet, production of thromboxane A2,and so inhibits aggregation of platelet and prevents thrombosis.Clopidogrel is a thienopyridine antiplatelet agent that inhibits ADP-dependent platelet activation and aggregation. And inhibits the bonding of fibrinogen and platelet, amplification of platelet due to ADP. Clopidogrel also inhibit the process of platelet-mediated intimal proliferation and smooth muscle hyperplasia.Platelet glycoproteinâ…¡b/â…¢a inhibitor can obviously inhibits theâ…¡b/â…¢a receptor on the platelet and the platelet aggregation due to blood coagulation factor.Its target site is the final stage of platelet aggregation, so Platelet glycoproteinâ…¡b/â…¢a inhibitor can inhibits the platelet aggregation significantly.The three kind of antiplatelet drugs have different clinical application method dosage and time because of different mechanism of action.and different disadvantage.further studys are needed to suggest better use to obtain more benefits.Conclusions: Antiplatelet therapy is foundation stone to prevent thrombosis in coronary artery bypass graft surgery.And it is so important that can not be substituted.Many researchs have confirmed the importence of aspirin an clopidogrel in the therapy of coronary artery disease. Platelet glycoproteinâ…¡b/â…¢a inhibitors have more effective to prevent thrombosis as a new kind of antiplatelet drug, and is perspective in the therapy of coronary artery bypass graft. But more researches are needed to give rational proposition.