Expression Of Serial Interleupins In Sera Of Patients With Allergic Rhinitis And /or Bronchial Asthma And Study About Relationship Between Allergic Rhinitis And Asthma

【Objective】To furtherly explore the effect of interleupin 4(IL-4),interleupin 5 (IL-5),interleupin 9(IL-9),interleupin 10(IL-10),interleupin 13(IL-13),interleupin 15(IL-15),interleupin 18(IL-18) in pathogenesis of patient with Allergic rhinitis(AR) and Bronchi asthma.Observe difference of interleupin between all groups.【Methods】33 patients with asthma,35 patients with AR,35 patients with AR accompanying bronchial asthma(BA) and 35 controls were included in the study.The concentration odd IL-4,IL-5,IL-9,IL-10,IL-13,IL-15,IL-18 in the sera was measured by double antibody sandwich enzyme-linked immunosorbent assay.【Results】The level of IL-4,IL-5.IL-9,IL-10,IL-13,IL-15,IL-18was greatly increased in every studied group than control group(P＜0.05).The level ofIL-5,IL-10,IL-15,IL-15 was greatly increased inAR accompanying bronchial asthma(BA) group than the group of asthma(P＜0.01),the group of AR(P＜0.01).There was statistical difference between the group of AR and AR accompanying bronchial asthma(BA) group in the serum level of IL-4,There was statistical difference between the group of AR and the group of bronchial asthma in the serum level of IL-5,IL- 18.【Conclusions】IL-4,IL-5,IL-9,IL-10,IL-13,IL-15,IL-18 may play a prominent role in the pathogenesis of AR and asthma.The serum level of it may reflect that asthma and AR.are developed by imbalance between T helper cell typesland 2 lymphocyte populations.The study shows that both AR and asthma are characterized by means of a similar inflammatory process.Interleupin may play an important role in the process.There was a close relation between the allergic inflammations of upper and lower respiratory tract.The difference between the group of AR and the group of bronchial asthma in the serum level of IL-5,IL-18.suggest there is difference in inflammations between allergic rhinitis and asthma.