Sero-epidemiological Survey Of Hepatitis B In The Population In Zhangjiagang City

Objectives: To understand the current infectious status and epidemic features of hepatitis B virus among the population in ZhangJiaGang City, as well as the inoculation status of Hepatitis B vaccines in different areas and people in ZhangJiaGang City; To evaluate the effect of immunization with hepatitis B vaccine after implementation of the Expanded Programme on Immunization(EPI), so as to provide scientific basis for the government to make measures to prevent Hepatitis B further.Methods: (1)Sampling Method:Apply multilevel and random sampling method. Take two towns from the nine towns of ZhangJiaGang City, then take one resident committee or one Villagers Committee of each selected town as the investigation scene. Set the age box of 1～4, 5～14 and 15～59 and use village, individual and family as the unit in the investigation scene to draw sufficient samples.(2)Survey Method:Send out a questionnaire survey to every respondent, and collect their venous blood, segment the serum and keep it under low temperature to examine related index(.3)Examining Method:Use ELISA to inspect the HBsAg, HBsAb and HBcAb. The inspection is undertaken in the Virus Research Department of Chinese Centers for Disease Control and Prevention. The inspection reagent ELISA is produced by InTec Products, Inc in Xiamen.(4)Statistical Method:Input all the material into the EpiData3.1database, and use SPSS13.0 to make statistical processing and analyzing.Results:(1)Demology Features:The respondents vary from area, age, sex, education level, occupation and marriage, etc, among which the constitution of people's age of 1～4, 5～14 and 15～59 people is 19.61%,30.32% and 50.08%;the ratio between male and female is 1:1.03(.2)Inoculation of hepatitis B vaccines:The average hepatitis B vaccine inoculation rate of the ZhangJiaGang citizens is 50.83%. There is no distinctive difference in the hepatitis B vaccine inoculation between people in different areas, while the inoculation rate of people under 15 years old(99.09%) is clearly higher than people above 15 years old(2.71%)(.3)Epidemic Serology Features as the sign of HBV infection: The rate of HBsAg Positive, HBsAb, HBcAb and HBV infection of the respondents is 5.73%(38/663), 52.19% (346/663), 24.43%(162/663)and 32.43%(215/663)respectively. There is no distinctive difference of HBsAg Positive Rate between people in the different areas. The HBsAg Positive Rate of people under 15 years old is obviously lower than that of people above the age of 15, There is no distinctive difference of HBsAb Positive Rate among which people from age of 1～4 and those age of 5～14.There is no distinctive difference between the HBsAg Positive Rate of male and female.Conclusion: Zhangjiagang has significantly reduced the HBsAg incidence rate and HBV infection rate by Hepatitis B vaccines implemented in the children's immunization program, leading to the change of Zhangjiagang from a high epidemic area to a middle one(2%≤HBsAg Positive Rate<8%). With the Hepatitis B vaccines added to the children's immunization program in 1992, the incidence of HBsAg Positive Rate among people under 15 years old has dropped largely, especially much larger among people under 5 years old, which primarily achieves the goal set by WHO West Pacific Area that HBsAg Positive Rate should be controlled under 2%, while the change of HBsAg Positive Rate among the children and adults above 20 years old is not notable.This proves that inoculating Hepatitis B vaccines in big scale is the most effective way to control HBV infection, and suggest that inoculation should be increased in adults, as well as strengthen the implementation in the people in the immunization program.