The Empirical Study On The Effect Of Anti-inflammation And Analgesia Of The Compatibility-composition Group About Radix Aconiti Kusnezoffi Preparata And Raidix Paeoniae Alba

Objective:Based the effect of anti-inflammation and analgesia about the water decoction about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba,the aim of this article is to approach the compatibility of composition group about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba on anti-inflammation effect, analgesia effect and deintoxication.Methods:It is to research research the compatibility effect of the water decoction and composition-group about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba on anti-inflammation effect,analgesia effect and deintoxication.On the water decoction deck,it is adoptted the water decoction of Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba 1:1,1:2,2:1,2:3,and,the pain test induced by hot-plate,the body-twisting test induced by acetic acid,the swelling test of the auricles induced by xylene,and cold and dampness syndrome rheumatoid arthritis model are used to research the different compatibility proportion effect of the water decoction about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba on anti-inflammation and analgesia.On the composition-group deck,the uniformdesign method is used to design the compatibility proportion of the composition-group,the pain test induced by hot-plate,the body-twisting test induced by acetic acid,the swelling test of the auricles induced by xylene,and the swelling degree test of feet induced by egg white are used to research the different compatibility proportion effect of the composition-group about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba on anti-inflammation and analgesia. The acute toxicity testing is used to research the toxicity and deintoxication of the composition-group compatibility about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba.Results:The compatibility water decoction about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba could elevate the pain threshold of mice induced by hot-plate and acetic acid,and restrain the swelling of the mouse auricles induced by xylene and the volume of Bi-Zheng rats's feet.The composition-group compatibility about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba could elevate the pain threshold of mouse induced by hot-plate and acetic acid,and restrain the swelling of the mouse auricles induced by xylene and the swelling of rat feet induced by egg white.Following the dosage of Radix Aconiti Kusnezoffi preparata total base increased,LD₅₀ of the composition-group compatibility about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba has diminished tendency obviously.Conclusions:the water decoction of Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba have obviously effect on the analgesia and anti-inflammatory,among them different proportion,the better ratios of analgesia and anti-inflammatory are 1:2 and 2:3 respectively.the compatibility of composition-group about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba have the effect of analgesia and antiinflammatory,key components playing a part in analgesia and antiinflammatory are different,and compatibility-proportion are different,the react times are different also.The following conclusions can be supposed from the optimized result of compatibility proportion in different times:Radix Aconiti Kusnezoffi preparata total base has strong analgesic effect,and react fast.The analgesic effect on total glucosides and polycose of Raidix Paeonia e Alba react slowly.on the anti-inflammatory effect,Maybe there is a double hump manifest on the the metabolism of Radix Aconiti Kusnezoffi preparata water-solubility alkaloid,total glucosides and polycose of Raidix Paeoniae Alba.Besides,following the dosage of Radix Aconiti Kusnezoffi preparata total base increased,the toxicity of the compatibility of composition-group about Radix Aconiti Kusnezoffi preparata and Raidix Paeoniae Alba is increased.But a few proportion of them have some deintoxication.