| Objective:To observe the influence of different dose of aspirin to the LPA level in patients with acute internal carotid circulation infarction.And to provide the basis for the preservation and intervention of the ischemic cerebrovascular disease.Methods:The patients resource was the patients with acute internal carotid circulation infarction in Heze Municipal Hospital neurological medicine department and the medical outpatients from 2007.3.1-2008.5.30.Then divided into two group①therapia group:132 patients with acute internal carotid circulation infarction,age 35-80 years old,average age 56.7±11.6s.All coincidence with the castigatory diagnostic criteria in the fourth nationwide congress,onset in 48 hours,verified by CT,the nervous system symptoms and signs were fit internal carotid circulation cerbral infarction.All Patients were randomly classified into two groups,within 48 hours,of which 66 were receiving 75mg/d(low-dose) aspirin tablet,and other 66 were receiving 150mg/d(high-dose) aspirin tablet.②30 cases normal healthy human adopted as control group,age 42-70 years old,average age 52.1±13.4s.They were not accompanied with important organ diseases such as heart,liver,especially ovary cancer.Took venous blood 4ml in specific days on an empty stomach,control group taken instantly,therapia group taken blood before taking aspirin and after taking 7days,2weeks,4weeks.The bloods were centrifuged for 10 minutes at 3500r/min.Took suction 1ml blood plasma to make LPA concentration measurement.Used ESS scoring the function turnover to the therapia group patients.All datas were analysed statistically by SPSS 11.0 statiatical software.One-way analysis of variance was adopted to compare multiple sample mean.The mean of the two sample were compared with t test.Results:1.Plasma LPA level in the patients with acute internal carotid circulation infarction before taking aspirin rose significantly,which were (4.06±1.23μmol/L)versus the control(1.77±1.03μmol/L)(P＜0.05)2.Except 2 cases stoping the study for the adverse reaction of aspirin,Patients with acute internal carotid circulation infarction took apirin 75mg/qd group or took aspirin 150mg/qd,group in 7days,the PLA levels were all reduced significantly,which was(2.70±1.42μmol/L )or(2.31±1.03μmol/L) versus the control (1.77±1.03μmol/L)(P＜0.05),among the total,the high-dose reduced significantly, which was(2.31±1.03μmol/L) versus the low-dose(2.70±1.42μmol/L)(P＜0.05).The LPA levels of the patients who took different doses of aspirin in 4weeks have no statistics significance(P＞0.05)。3.Score the function to the two therapia groups patients use ESS.The score in 2weeks versus before overdose improve significantly,and 150mg/d group improve more obviously;the score in 4weeks have little difference.conclusion:The results of this study showed that the LPA level rose obviously in patients with acute ischemic cerebrovascular disease,taking aspirin tablet could reduce the content of plasma LPA.Proved LPA increased in close contact with platelet activation,aspirin may be ways to inhibit COX-inhibiting platelet activation,and thus inhibit the platelet-activating to have a process of LPA generating.After cerbral infarction two weeks,low-dose aspirin could control the stability of the LPA content,which may be provide the base to looking for the optimal dose of cerebral infarction for the secondary prevention.
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