Analysis Of The Relationship Between Hyperuricemia And Metabolic Syndrome In A Health Examination Cohort In Beijing

Objective: To evaluate the relationship between hyperuricemia and metabolic syndrome in a health examination cohort in Beijing.Methods: We conducted a cross-sectional study in a cohort of 3407 individuals (1830 men and 1217 women) who participated in annual health examinations at the Peking Union Medical College Hospital from September to December 2005. We estimated the prevalence of hyperuricemia and metabolic syndrome, and analysed the relationship between hyperuricemia and metabolic syndrome in the cohort.Results: The overall prevalence of hyperuricemia was 9.7%, but it was higher in men than in women(11.6% vs. 6.7%, p<0.001). The overall prevalence of metabolic syndrome was 19.6%, however it was higher in women than in men (25.0% vs. 16.1%, p< 0.001). The prevalence of hyperuricemia in the analysed group was 9.0%, but it was higher in men than in women(11.6% vs. 5.2%, p<0.001). The prevalence of metabolic syndrome in the analysed group was 33.9%, however it was higher in women than in men(29.4% vs. 40.5%, p< 0.001). Serum urate levels increased in groups of individuals with more components of metabolic syndrome. After adjustment for age, clearance of creatinine, total cholesterol, HDL-C, smoking and drinking status, the risk of metabolic syndrome in individuals with hyperuricemia(odds ratio, 95% CI) was 3.035(1.877-4.908) in men, and 5.114(1.789-14.620) in women. In contrast, the risk of metabolic syndrome(odds ratio, 95% CI) in sex-specific quartiles of serum urate was 1.936(1.180-3.176), 2.412(1.499-3.880), and 4.592(2.794-7.547) in men, and 1.862(1.030-3.366), 2.449(1.346-4.456), and 5.129(2.840-9.263) in women.Conclusions: Serum urate level is an independent risk factors associated with metabolic syndrome. The prevalence of metabolic syndrome is significantly higher in individuals with hyperuricemia. Even in individuals within normal serum urate range, the prevalence of metabolic syndrome is higher as serum urate levels increase. Further studies are needed to explore the mechanism for the close relationship between them.