The Clinical Value Of Combined Assay Of Serumal Matrix Metalloproteinases-9 And C-reactive Protein In Patients With Coronary Artery Disease

Objectives: To determine the value of detection of serum level of C-reactive protein (CRP) combined with matrix metalloproteinases-9(MMP-9) to study stability of AS plaque in patients with coronary artery disease.Methods: Using ELISA and scatter rate nephelometry, serum matrix metallproteinse9 (MMP-9) and C-reactive protein(CRP) were measured in 38 patients with acute coronary syndrome(ACS),24 with stable effort angina(SA) and 24 normal control subjects. Then the level of LDL was detected. All patients underwent coronary angiography. The characters of angiographic morphology of coronary arteries were analyzed.Results: (1):The serumal levels of CRP and MMP-9 in ACS group were significantly higher than SA and control groups(p<0.05).But there were no different significance between SA group and control group (p>0.05);(2):The level of LDL was not significantly different among groups.(3):The level of CRP in ACS group was significantly correlated with the character of angiographic morphology of coronary arteries as well as that of MMP-9;(4):But the correlation between CRP and MMP-9 in ACS group was not significantly different.Conclusions: The increased serumal levels of CRP and MMP-9 in patients with coronary artery disease may predict the unstable conditions of plaques.The fact that there was no correlation between CRP and MMP-9 suggests that the different aspects which predict the unstability of plaques.It may be more beneficial to predicting the stability of AS plaque and forecasting acute cardiovascular risk by combination detection of serumal levels of CRP, MMP-9.