ShenFu Injection Treatment Of Chronic Congestive Heart Failure Clinical Research

Objective:The incidence rate on Congestive Heart Failure is high.It' s five year survival rate similar with malignant tumor.It seriously threaten the life safety of manking and has already been a very important public hygienic problem.The aim of the research is to reduce the mortality and relapse rate,at the same time improve the patients' clinical symptom and living standards by treatment with integrated WM and TCM.To observe the therapeutic effect of these patients treated with ShenFu injection and investigate its functional mechanism and applied prospect.Methods 42 patients with Congestive Heart Failure were divided into treatment and control groups randomly.Among 22 cases in the treatment group,male patients were 12 and female 10.The average age was 63.4 years old.Two cases were Grade 2 heart failure,8 cases Grade 3 and 12cases Grade 4.Among 20 cases in control group,10 cases were male and 10 cases female.Their age averaged 65.3 years old.two cases were Grade 2 heart failure,8 Grade 3,and 10 were grade 4.The general condition of two groups of patients had no statistic difference.All belonged to Yang weak,blood stasis retention according to TCM.The control group were treated with traditional comprehensive therapy of WM,including controlling infection,smoothing the respiratory tract, continuing breathing in oxygen on two rate of flow,strengthening the heart,diuresis,expand blood vessel,correcting the unbalance between acid and alkali and turbulence of electrolyte,etc;Treatment group in the above-mentioned treatment services based on ShenFu injection,Pharmaceutical ingredients:ginseng,monkshood.Twice a day,intravenous administration,One course is 7 day.Compare the symptoms,signs of two groups of patients and changes of indexes. Results:1.Comparison of the clinical curative efficacy on two groups of patients:After treatment,the changes in symptoms and signs of two groups were both effective.The treatment group was prior to the control group significantly(P<0.05).It shows that the additional use of ShenFu injection can improve clinical treatment effect of patients with Congestive Heart Failure compared with therapy of WM alone.2.Comparison of improvement in the patients' cardiac function examinations:After treatment,comparison of the the ejection fraction of left ventricle,the treatment group was prior to the control group significantly(P<0.05).The LVEF of post-treatment comparison of pretreatment were both obviously improved both the two groups.3.Comparison of improvement in the patients' symptom integra of Congestive Heart Failure:After treatment,symptom integra of the two groups of patients decreased both.But the treatment group showed a great difference(P<0.05).4.Comparison of improvement in the patients' symptom integra of every symptom:Comparing pre-treatment with post-treatment,the groups of patients' symptom integra of every symptom decreased,and every of the treatment group' s symptom showed a great difference(P<0.05).5.There is no obvious badness response on two groups of patients. Conclusions:ShenFu injection can improve the symptoms and signs of the patients with Congestive Heart Failure obviously.X-ray and heart ultrasonic examination are remarkedly effective.In control group,the patients' symptoms, signs and supplementary examinations have improved in varying degrees.But through SPSS statistic software' s process,the treatment group was superior to the control group significantly(P<0.05).In conclusion,the efficacy of additional use of the ShenFu injection is better than the efficacy of therapy of WM alone.It can also improve the patients living standards.