Serum S100 Protein And Cerebral Radiation Injuries In Brain Malignant Tumor: A Revaluate

Objective To study the value of serum S100B protein in the diagnosis of cerebral radiation injuries in the patients with brain malignant tumor.Methods Serum S100B protein levels were detected by enzyme-linked immunosorbent assay in 56 patients with brain malignant tumor in the course of radiotherapy.Compare the differences among the status of radiotherapy,the methods of radiotherapy,peritumoral edema and Karnfsky performance status.Results The levels of serum S100B protein before,in the middle of and after radiotherapy were 0.044ug/l,0.049ug/l,0.079ug/l,respectively,showing significant difference (X2=67.261 P=0.0001)between these times points measurement.And the levels of serum S100B protein after radiotherapy have significant differences among the three methods of radiotherapy(F=20.323 P=0.0001).So do the degree ofperitumoral edema(F=12.938 P＜0.001) and Karnfsky performance status(t=2.710 P=0.007).Conclusion High levels of serum S 100B protein are associated with cerebral radiation injuries in brain malignant tumor and are influented with the dose of radiotherapy,the methods of radiotherapy,Karnfsky performance status and degree of peritumoral edema.So high serum S100B level may serve as an early predictor of the injury.