Traumatic Brain Injury Patients With Cerebrospinal Fluid Myelin Basic Protein Content And Clinical Significance

Objective:Acute brain injury patients' different levels of myelin basic protein(MBP) in cerebrospinal fluid(CSF) and it'sclinical significance.Methods:Using ELISA to measure MBP in CSF with 40 cases of patients with acute brain injury[mild(GCS 9-15 points),heavy(GCS 3-8 points) 20 cases]1,3,7 days after trauma and another 15 cases in the spinal anesthesia of our hospital over the same period line to be hospitalized outside the spinal surgery for non-trauma patients in the control group.The statistical methods are using repeated measure analysis of variance.Results:1 MBP level in CSF with Brain Injury was significantly higher than the control group and there is significant difference,P<0.01;MBP levels in cerebrospinal fluid of group in the heavy medium-sized group were higher than the light,there is significant difference,P<0.01;2 MBP and GCS,GOS were significantly negatively correlated.(P<0.01).Conclusion:MBP is a high sensitivity and specificity of nerve cell injury markers.MBP in cerebrospinal fluid levels and the severity of brain injury and prognosis are closely related.Brain Injury Patient MBP detection in cerebrospinal fluid could be used as the severity of brain injury and an important indicator of prognosis prediction.