Retrospective Analysis Of Patients With Primary Aldosteronism

Objectives: To improve the diagnosis and treatment of primary aldosteronism(PA).Patients and methods:A total of 125cases of PA patients with intact laboratory datas and reception of surgical treatment ,also having histopathology verification who were enrolled in the second hospital of Hebei Medical University from April 2008 to December 2008,were included in the study ,including 47 males and 78 females.According to the 125 cases of patient's clinical manifestations, laboratory tests, imaging examinations, the results of clinical trials and surgical treatment, pathological findings and the characteristics of drug treatment ,we analyze and summarize them.And do follow-up to the patients from 3 months to 11 years.Results:125 cases of patients have surgical treatment, including 114 cases of adrenocortical adenoma(APA), 9 cases of adrenal hyperplasia (IHA)and 2 cases of adrenocortical carcinoma (APC).86 cases of adrenal cortical adenoma and 1 cases of adrenal hyperplasia are cured, the blood pressure and serum potassium of 1 case ofAPC patients return to normal, the blood pressure of 28 cases of adenoma and 8 cases of adrenal cortical hyperplasia patients are lowering, which still need drugs to control .Conclusions: Spironolactone test and serum aldosterone assay are the main methods of PA qualitative diagnosis.Location test and ultrasongraphy exam would be help to differentiate adrenal adenomas and adrenocortical hyperplasia. PA location mainly relies on the type-B ultrasonic and CT. Surgery is an important method for the treatment of PA.APA patients are better with extraction from affected adenoma, IHA patients mainly rely on drug treatment, if it is ineffective or nodular hyperplasia in particular unilateral, should be considered to be extracted from affected adrenalectomy. The affective factors of therapeutic effection mainly related to patient age, history of long, deep hardening of the arteries, and therefore the early diagnosis of PA, treatment is essential for the rehabilitation of patients.