Relationship Of C-reactive Protein And Abdominal Fat Distribution In Type 2 Diabetes Mellitus

Objective: By measuring visceral fat area (VA), subcutaneous fat area (SA) and C-reactive protein levels in the normal(NC group), type 2 diabetes patients without obesity(C group) ,type 2 diabetes patients with non-visceral obesity(B group) and type 2 diabetes patients with visceral obesity(A group) to explore relationship between C-reactive protein and abdominal fat distribution in type 2 diabetic patients.Methods: In accordance with the 1999 World Health Organization (WHO) diagnostic criteria for diabetes to develop, select 36 patients with type 2diabetes for this study our hospital. According to waist circumference (man≥85cm, females≥90cm,to navel horizontal), they were divided into two groups: type 2daibetes patients with or without obesity. According to area of visceral fat, type 2 diabetes patients with obesity were divided into two group: type 2daibetes patients with or without visceral obesity. Take 15 people as normal controls. The subjects were measured height, waist circumference, weight, hip circumference, fasting blood glucose testing(FPG), lipid(TC, TG, LDL-C, HDL-C), Apo lipoprotein(A, B), blood pressure, fasting insulin(FINS) and C-reactive protein levels, subcutaneous fat area and visceral fat area. All of body mass index (BMI), waist-hip ratio(WHR), insulin resistance index(HOMS-IR), and visceral/subcutaneous area ratio(VA/SA) were calculated. Comparison among the three groups of fasting blood glucose, blood lipids, blood pressure, fasting insulin, insulin resistance index, waist-hip ratio, C-reactive protein, subcutaneous fat area, visceral fat area, visceral/subcutaneous area ratio; observation of C-reactive protein and abdominal fat the relevance of the distribution area. All data were expressed as mean±SD, or median. Statistical comparisons were done by Pearson and Spearman analysis.Result: 1. C-reactive protein in A group were significantly higher than the normal control (P<0.01); C-reactive protein levels of B group and C group higher than the normal control (P<0.05). C-reactive protein in A group were significantly higher than B group and C group (P<0.05); C-reactive protein in B group were significantly higher than C group(P>0.05); From the normal control, C group, B group to A group, C-reactive protein levels increased in turn.2. Visceral fat area in A group, B group and C group was significantly higher than that of normal control (P<0.01); Visceral fat area in A group was significantly higher than that in B group and C group (P<0.05); visceral fat area in B group higher in C group (P>0.05); subcutaneous fat area of A group, B group, C group was higher than that of normal control (P<0.05); subcutaneous fat area in B group was higher than that in C group (P<0.05); subcutaneous fat area of A group and was higher than that in B group and C group(P<0.05); VA/SA ratio of A group, B group and C group was significantly higher than that of normal control (P<0.01); VA/SA ratio of A group and B group was significantly higher than that of C group (P<0.05); VA/SA ratio of A group was significantly higher than that of B group (P<0.05).3. C-reactive protein levels were positively correlated with waist circumference, visceral fat area, subcutaneous fat area, waist hip ratio, insulin resistance index, low density protein, body mass index, fasting glucose testing. C-reactive protein levels were positively correlated with waist circumference, visceral fat area, subcutaneous fat area, VA/SA after adjusting HOMA-IR, FPG.Conclusion: Compared with normal control group, C-reactive protein levels with type 2 diabetes patients significantly increased, suggesting that there is a certain degree of chronic inflammation process in type 2 diabetes patients. C-reactive protein levels activity increased with visceral fat. Visceral fat reduction is very important solution for type 2 diabetes patients to reduce inflammation in vivo.