Clinical Review Of 7 Primary Biliary Cirrhosis

Purpose:For primary biliary cirrhosis (PBC) patients were retrospectively analyzed the clinical characteristics, diagnosis and treatment of the disease in order to improve the understanding, be helpful for early diagnosis and early treatment, improve the prognosis.Methods:On January 2002 to May 2008, 7 cases of patients with primary biliary cirrhosis of the clinical data were analyzed.Results:The patients were six women and one men,aged 49~67 years old, the average 56.6±6.9 years.Symptoms,with jaundice (85.7%) most, followed by itchy skin (57.1%) and fatigue (57.1%).Four patients (57.1%) had liver or spleen enlargement,three patients (42.9%) cases esophageal varices, two patients (28.6%) merger ascites.All patients elevated serum alkaline phosphatase about 404.7±130.4 U/L, six patients (85.7%) elevated glutamyltranspeptidase about 544.5±244.2 U/L, six patients (85.7%) elevated total bilirubin about 35.6±130.1U/L,and mainly direct bilirubin elevated about 159.7±51.1μmol/L.Five patients (71.4%) test serum immunoglobulins leels significantly increased of IgM about 4.2±0.77 g/L,and IgA,IgG level for more than normal or slightly increased.And then six patients (85.7%) tested antimitochondrial antibody positive for inspection;A patient tested antimitochondrial antibody for negative, but the pathological changes in accordance with the line of liver biopsy disease . All patients are used to bear deoxycholic acid treatment.Conclusion:Primary biliary cirrhosis, mainly involves the middle-aged women, jaun-dice, itchy skin, etc,clinical manifestations;serum alkaline phosphatase, glutamyl-transpeptidase and bilirubin rise,Antimitochondrial antibodies (AMA) detection,liver biopsy and imaging studies may do contribute to the diagnosis.Treatment of frist choice is bear deoxycholic acid (UDCA).If the inefficiency of medical treatment should make liver transplantation as soon as possible.