The Change And Significance Of MMP-9 In The Patient Of Fetal Growth Restriction

Objective:To investigate the relationship between matrix metalloproteinases-9 (MMP-9) and fetal growth restriction,we detected the concentration of MMP-9 in elbow vein blood from pregnant women with fetal growth restriction (FGR) and umbilical vein blood from their newborns.Methods:Twenty pregnant women of fetal growth restriction and their newbomes (the FGR group),twenty normal pregnant women in term and their newbomes (the normal group)were studied.The concentration of MMP-9 in maternal elbow vein blood and umbilical vein blood were determined by solid phase sandwich enzyme linked immuno-sorbent assay(ELISA).These experimental data was analized by the software SPSS13.0.Results:(1) The level of MMP-9 in maternal elbow vein blood of FGR group was(103.00±38.71)ng/ml,the level of MMP-9 in maternal elbow vein blood of the nomal group was(196.60±78.91 ) ng/ml,the level of FGR group is lower than the nomal group,the two groups had statistically significant deviation(P＜0.001).(2) The level of MMP-9 in umbilical vein blood of FGR group was(80.30±30.47) ng/ml,the level of MMP-9 in umbilical vein blood of the nomal group was(153.80±83.62) ng/ml,the level of FGR group is lower than the nomal group,the two groups had statistically significant deviation(P＜0.05).(3) The levels of MMP-9 in maternal elbow vein blood were higher than the levels of MMP-9 in umbilical vein blood in both of the the FGR groups and the nomal groups(p＜0.05,p＜0.05),and the levels of MMP-9 in maternal elbow vein blood were positive correlated with the levels of MMP-9 in umbilical vein blood in both of the FGR groups and the nomal groups(r=0.593,r=0.624).(4) The levels of MMP-9 in both of maternal elbow vein blood and umbilical vein blood were positive correlated with the birth weight of newbomes in the FGR groups(r=0.476,P＜0.05;r=0.567,P＜0.05),the levels of MMP-9 in both of maternal elbow vein blood and umbilical vein blood was not correlated with the birth weight of newbornes in the nomal groups(P＞0.05,P＞0.05)Conelution:It showed that the significantly reduced levels of MMP-9 in both in maternal elbow vein blood and umbilical vein blood of fetal growth restriction,and the levels of MMP-9 were positive correlated with the birth weight of newbomes in the FGR groups,but the levels of MMP-9 was not correlated with the birth weight of newbornes in the nomal groups, MMP-9 had improtant actions in occurrence and development of FGR,it may be one of the new indicater of predicting FGR.