| The main components of Shuanghuanglian injection Phillyrin,honeysuckle, Scutellaria,has heat-clearing and detoxifying role for exogenous wind-heat, coughing shortness of breath,sore throat,acute upper respiratory tract infection,acute bronchitis,acute tonsillitis,pneumonia light Clinical combination with antibiotics,with the merger cefradine hematuria after the medication,reports of liver injury,the mechanism is unknown,it is limited in clinical use.Cefradine for the first-generation cephalosporins,because of its antibacterial activity,and a broad spectrum antibiotic,side effects, affordable,etc,were widely used in clinical treatment of respiratory tract infections,urinary and reproductive tract infections such as skin and soft tissue infections,to achieve a satisfactory results.However,recent reports from the domestic cefradine adverse reactions can be found in medical journals, hematuria cefradine adverse reactions lead to a larger proportion.Manuals and a variety of drugs and medicines are annotated brochure cefradine toxic to the kidneys can cause minor to prompt adverse reactions hematuriaWith the injection cefradine clinical(especially at the grass-roots hospital) a wide range of applications,the adverse reactions reported is increasing year by year.Apart from hematuria,there are anaphylactic shock, delayed hypersensitivity,hemolytic anemia,hearing loss,cardiac arrhythmia, such as dysuria reported adverse reactionsWhat is noteworthy is that the clinical antibiotics and the combined use of Shuanghuanglian injection has reached 82.97%.There are cases showed that patients using cefradine Shuanghuanglian injection and after the combined treatment of hematuria This study is designed to:Manual in accordance with:the provisions of the highest dose of adult day 8g,specific dose-dependent reduction in use with a doctor with the condition experience a change in the different dose and under different circumstances Shuanghuanglian combined with freeze-dried powder drugs,dose 60mg/kg,through the injection of different doses of Shuanghuanglian cefradine combined liver and kidney toxicity study of drug use to further explore in order to prove that the merger between the two drugs would have a liver and kidney toxicity as well as its dose and time appear the relationship between the evaluation of the merger in the dose of medication is safe and reasonable use and the design of clinical trials provide the basis for administration of the program.Specific studies are as follows:1.Shuanghuanglian injection combined with medication cefradine nephrotoxicityExperiment is divided into eight groups,solvent control group, Shuanghuanglian group(387.273 mg·kg-1),low-dose cephalosporin group(207.47 mg·kg-1)?cephalosporins in the dose group(414.94 mg·kg-1)?high-dose group Pivoxil(829.87mg·kg-1),the combined use of high-dose group(Shuanghuanglian 387.273 mg·kg-1+cefradine 829.87mg·kg-1);combined medication dose group (Shuanghuanglian 387.273 mg·kg-1+cefradine 414.94 mg·kg-1);combined use of low-dose group(Shuanghuanglian 387.273 mg·kg-1+cefradine 207.47 mg·kg-1).Observation of the combined use of renal toxicity in rats.Detection of indicators include:malondialdehyde(MDA),superoxide dismutase(SOD), glutathione peroxidase(GSH-PX);urine N-acetyl-β-D-glucosaminidase(NAG) and urinary alkaline phosphatase(AKP),creatinine(Cr) blood urea nitrogen (BUN),urine protein,urine volume,total cholesterol.Combined treatment group in this experiment with the cephalosporin group,Shuanghuanglian group, solvent control group,urinary protein,creatinine:one of three groups combined with the drug solvent,respectively,difference between the control group were significantly p<0.01;renal tissue GSH - Px vitality,SOD,MDA contents,urine NAG dynamic significant change of the dose-dependent relationship can be seen in the experimental study of the scope of the test dose,combined drug for anti-oxidation in kidney tissue of the role of both active substance content certain extent.Biochemical blood analysis and indicators show that the combined treatment group compared with the solvent control group differences p<0.05,suggesting a certain degree of renal toxicity.2.Shuanghuanglian injection cefradine combined with the liver toxicity of drugs.Observation of combined drug toxicity on rat liver.Detection of indicators include: alanine aminotransferase(GTP),aspartate aminotransferase(GOT),the Organization of malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-PX); serum N-acetyl-β-D-glucosaminidase(NAG) total bilirubin(T.Bili),total protein.Liver tissue GSH-Px vitality,SOD,MDA content,dynamic changes of serum NAG and solvent control group there are differences,but also a significant dose-dependent relationship can be seen in the experimental study of the scope of the test dose,the combined medication for the liver organizations in the anti-oxidation effect,the content of active substances have a certain impact.Prompted a certain degree of liver toxicity.3.Combined use of blood and related physiological effects of constantObservation of the combined use of rat liver and kidney organ coefficient of blood,as well as the impact of the major indicators,including blood testing of white blood cells,red blood cells,platelets,lymphocyte percentage, hemoglobin.Experimental results show that:there was no red blood cell group differences in the p>0.05;platelet medication combined low-,medium-dose group and control group no significant difference p>0.05,the combined use of high-dose group and control group difference p<0.05;the remaining indicators are combined high-dose group and control group difference p<0.05, difference with the combined dosage significantly increased;rat liver kidney coefficient device is no difference between the groups shows that the combined use of the indicators of the impact is not great. |
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