Development And Evaluation Of The Liver Disease PRO Scale For Ascites Of Hepatocirrhosis Patient

Objective:Through the clinical investigation with large samples and multicentre,test the reliability,validity and responsiveness of the pre-questionaire,the Liver Disease Patient Reported Outcome(PRO) Scale of Traditional Chinese Medicine(TCM) is going to be used for liverish evaluation of curative effect of TCM.Methods:1.On the basis of Yang xiaolan's study,which was Development and Assessment of the Liver Disease scale of Traditional Chinese Meicine (TCMLD-Scale) for Liver Cirrhosis Patient,the pre-questionaire was used in the field investigation.By applying 6 kinds of statistical methods,including the coefficient of variation analysis,factor analysis,cluster analysis, stepwise regressive analysis,Crobach'sαcoefficient analysis and discriminatory analysis,63 items were composed of the formal scale.Then the formal scale was tested its reliability,validity and responsiveness. Reliability included split-half reliability and internal consistency; Validity included content validity,construct validity and discriminated validity.2.At the same time,adopting SAS and SDS for all objects.Use Stat software to analyse complexion of SAS and SDS.Thereby,providing therapy and beforehand for curative effect.And then provide attestation for lead patients' mind.Results:1.The Liver Disease(ascites of hepatocirrhosis ) PRO Scale of Traditional Chinese Medicine was mainly composed of 5 domains,14 facets and 63 items.The scale's Split-half reliability coefficient was 0.720,The scale's Split-half reliability coefficient of physiological domain, psychological domain,independent domain,social relationship domain,and environmental domain were 0.765,0.748,0.813,0.670 and 0.767.The scale's Cronbach'αcoefficient was 0.964,the Cronbach'αcoefficient of physiological domain,psychological domain,independent domain,social relationship domain and environmental domain were 0.952,0.942,0.950,0.951,0.974 respectinely.About construct validity,eight factors' dedication rate was 52.317%;every facet and domain had distinguished healthy people and patients effectively(P<0.05).Responsiveness:there was significant difference between pre and post treatment on blooding,controlling dredging emotion,transporting spleen-stomach,controlling dredging bile,positive feeling,attention,physiological domain and total scores(P<0.05),the correlation coefficients on the Liver Disease(Liver Cirrhosis) PRO Scale of Traditional Chinese Medicine,subjective response scale and the standard of liver cirrhosis ascites clinical curative effect,the facets of medical care, social entironment,attention were 0.412,0.439,0.332 respectively.The rest were smaller than 0.3.2.There was 40.29%of low-grade suspense,49.25%of middle-grade suspense,8.97%of high - grade suspense in the patient's group.The total of incidence of a disease was 98.51%.There was 60.32%of low-grade suspense,1.59% of middle-grade suspense in the healthy group.The total of incidence of a disease was 61.91%.There was 40.3%of low-grade dumps,40.3%of middle-grade dumps,4.5%of high - grade dumps in the patient's group.The total of incidence of a disease was 85.1%.There was 1.59%of middle-grade dumps in the healthy group.The total of incidence of a disease was 1.59%.Comparing the patient's group with the healthy group in enter hospital and leave hospital.The former,the total of incidence of a disease in SAS and SDS all hyper than the latter(P <0.001).Comparing the patient's enter hospital with leave hoapital of SAS and SDS.The latter was proved better than the former(P<0.001).The correlation coefficients on SAS of controlling dredging bile, controlling dredging emotion,transporting spleen-stomach,negative feeling, psychological domain and physiological domain had significant difference(P <0.05 ).The correlation coefficients on SDS of treatment on blooding, hemorrhage,controlling dredging emotion,transporting spleen-stomach, positive feeling,attention,individual ability,daily life ability,social life,psychological domain,physiological domain and independent domain had significant difference(P<0.05).In all patients,their course of diseases and age had significant difference of correlation coefficients with SAS and SDS(P<0.01).Conclusion:The scientific assessment had proved that the Liver Disease (Liver Cirrhosis) PRO Scale of Traditional Chinese Medicine had good reliability,validity and certain responsiveness.It was very effective to test the curative effect of TCM for patients with ascites of hepatocirrhosis.