The Study Of RA Rabbit Model By High Frequency Ultrasonograpy

ObjectiveThe suprapatellar bursua,synovial membrane,femoral condylar cartilage and subchondral bone cortices of RA Rabbit Model were ultrasonographically examined to find out the ultrasound adjuvant diagnosis on early-rheumatic arthritis. Material and MethodsRA Rabbit Model group: 15 early RA rabbits of the same weight and variety Control group:10 normal rabbits of the same weight and varietyMethods of making RA rabbit model:elect 15 normal rabbits of the same weight and variety, dissolve Ovalbumin in 0.9% sodium chloride solution, to make the solution of 20mg/ml concengtration, blend the same quantity of complete Freund′s Adjuvant(CFA) equably ,inject the mixed solution into endermic tissue of the rabbit′s scapular section, making the rabbits allergic, inject 1 ml of the mixed solution to one rabbit every time, inject 1 ml of the mixed solution in 5 different places of the rabbit′s scapular section, inject the rabbit one time every week,inject 3 weeks continuously,it turned out to be that the rabbits will be allergic, inject Ovalbumin blent with the 0.9% sodium chloride solution into the knee joint cavity of the rabbits in the fourth week, 5 mg Ovalbumin every knee joint cavity,two knees of every rabbit of the 15 rabbits are both injected,the arthrosis diameter and the exterior temperature of the knees will be added obviously in 24 hours,and they will drop gradually,at the time of the 14th or 21th day, the arthrosis diameter and the exterior temperature of the knees will get to the balance time,the incidence rate of RA is 100%.after the RA model succeeds,it is the early time of RA from the first week to the fourth week,after the fourth week,it is the late time of RA, the cartilage of the femoral condyle and the subchondral bone cortices will be changed unrecoverily.The suprapatellar bursua,synovial membrane,femoral condylar cartilage and subchondral bone cortices of RA rabbit Model were ultrasonographically examined.ResultsThe suprapatellar fluid and synovial membrane in RA model group were thicker than in the control group,the cartilage of the femoral condyle is almost same as the control group,and the subchondral bone cortices don′t have any changes compared with the control group.ConclusionsUltrasonography is valuable for adjuvant diagnosis and assessment of early-rheumatic arthritis.