The Clinical Significant On The Expression Of The P16 And CyclinD1 In Blood Lymphocyte In Postoperative Patient With Gastrointestinal Cancer

Objective: To analogy the clinical significance on the expression of P16 and cyclinD1 in blood lymphocyte in postoperative patient with gastrointestinal cancer.Methods: Flow cytometry was used to detect the expression of the P16 and cyclinD1 in blood lymphocyte in three groups:43 healthy peoples for control group,52 patients who were operated as gastrointestinal cancer one year ago,were divided into stable group and advanced group according to the clinical outcome. The expression in the three groups was analogy by Kruskal-Wallis H test and mann-whitney U test;Darw the Roc curve to definite the curital value ,and calculate the sensitivity and specificity of the P16 and cyclinD1.Results: The expression of the P16 and cyclinD1 in peripheral blood lymphocyte were significantly different in the three groups(P < 0.001),and the expression of the P16 and cyclinD1 in advanced group was significantly higher than those in control group and stable group(P < 0.001), the expression of the cyclinD1 in stable group had no significant difference with control group(P >0.05),but The expression of the P16 in stable group was higher than that in control group(P < 0.001).Draw the Roc curve to definite the critical value of recidivision:P16 was 6.71,cyclinD1 was 6.22;The sensitivity and specificity ;P16 was 82.4%,80.0%,respectively,cyclinD1 was 76.5%,85.7%,respectively.Furthermore,the sensitivity and specificity of the combinative detection of the two index was 82.4%,94.3%,respectively.Conclusion: It is important that The high expression of the P16 and cyclinD1 in blood lymphocyte to judge of the recidivation and prognosis of gastrointestinal cancer.