Study Of The Relationship Between Blood-pressrue Regulation And NE,E,PRA,Angâ…¡ In Center And Periphery After Acute Intracerebral Hemorrhage In Spontaneously Hypertensive Rats

ObjectiveTo study the levels of noradrenaline (NE ),adnephrin(E),angiotensinⅡ(AngⅡ)and rennin (PRA) in acute phase of SHR (Spontaneously hypertensive rats)with hypertensive intracerebral hemorrhage(ICH),dicussing the relationship between blood-pressrue regulation and NE,E,PRA,AngⅡin center and periphery after acute intracerebral hemorrhage of SHR.MethodsThe ICH model was established by infusing collagenase into rat caudate nucleus.The changes in NE,E in plasma and hypothalamus were determined with high–performance–liquid chromatography before the experiment and at1,3,7and14 days(five groups) after the establishment of ICH. AngⅡlevels and Renin activity were examined by radioimmuno-assay.Results1,The SHR appeared different degrees of behavioral change after ICH,the Bederson tests were nearly over 2 (2.33±0.701).2,NE,E activity in plasma and hypothalamus increased simultaneously 1 day after ICH and peaking at 24 hour(sits probability is 0.011,0.015,0.005),and recovered at the seventh to fourteenth.3,PRA,AngⅡactivity in plasma and hypothalamus increased simultaneously 1 day after ICH and peaking at 3 days( its probability is 0.035,0.036,0.024 ),and recovered at the seventh to fourteenth.4,The blood pressure in SHR significantly increased after ICH at the first day(its probability is0.000),and at the third day, it reduced significantly compareing with the first day,and recovered at the seventh to fourteenth. Conclusions1,The ICH animal model of collagenase injected into caudate- putamen nuceus in SHR was stable2,The activation excitability of sympathoadrenomedullary system and renin angiotensin system may play an important role in the blood-pressrue regulation after acute intracerebral hemorrhage.