| The purpose of this study was to observe the changes of the hemodynamics and pulmonary histopathology in acute spinal cord injured rats during isoflurane inhalation, to investigate the relationship between neurogenic pulmonary edema(NPE) and the changes of substance P in serum and bronchoalveolar lavage fluid (BALF). Epidural balloon compression of the T8 spinal cord was performed.Blood pressure and heart rate were monitored during surgery. Observed the changes of the pulmonary pathology and lung wet/dry weight ratios(W/D). The content of substance P and protein concentration in serum and BALF were measured. Then the lung permeability index (LPI) was calculated. 1.5% isoflurane can promote the development of neurogenic pulmonary edema in rats with a compressed spinal cord, which may be due to the uninhibited severe systemic sympathetic over excitation. 1.5% isoflurane also may stimulate the release of substance P to take part in the development of neurogenic pulmonary edema in rats with a compressed spinal cord. |
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