The Effects Of Gastrointestinal Reconstruction Following Gastrectomy On Regulating Glucose Metabolism In T2DM Patients

Objective:To discuss the effect of gastrointestinal reconstruction following gastrectomy on regulating glucose metabolism in T2DM patients. Methods:From August 2007 to July 2008, 820 patients who underwent gastrectomy were enrolled in a surgically supervised program.All patients were divided into 3 groups depending on the different types of reconstruction(12 patients have Billroth II gastrectomy, 6 patients have Total gastrectomy with Roux-en-Y gastrojejunostomy). Preoperative assessment included general clinical history that of T2DM and diabetic medication type.We evaluate pre- and postoperative clinical parameters (BMI,EWL%,HOMA-IR,HOMA-β) associated with improvement of diabetes up to 6 month after operation .Results: Fasting plasma glucose and glycosylated hemoglobin concentrations tests and clinicaloutcomes suggest:all the three types of reconstruction following gastrectomy resulted in significant improvement or resolution of T2DM in all12 patients. Patients with the shortest duration, the mildest form of T2DM (diet controlled), and the greatest weight loss after surgery were most likely to achieve complete resolution of T2DM. Conclusion: All the two types leads to improvement or resolution of T2DM. These results display Gastrointestinal reconstruction play a important role in treating T2DM. The results of HOMA-IR and HBCI suggest the recovery of insulin sensitivity andβ-cells function. Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery...