The Preparation Research Of Solid SMEDDS For β-elemene

The S-SMEDDS ofβ-elemene was prepared to improve the bioavailability ofβ-elemene. The content ofβ-elemene in Microemulsion and the plasma was determined by HPLC. The oil phase, surfactant and Cosurfactant was choosed by solubility experiments, at the same time, some saponins with the similar pharmacologic action asβ-elemene are chosen to be the emulsifying agent. The prescription was optimized and determined by the areas of self-microemulsion in Pseudo-ternary phase diagram, the size of particles and drug loading. Study adsorption materials, and determine preparation process. Do experiments of the initial stability and the vitro dissolution. Do the pharmacokinetic experiment of the S-SMEDDS ofβ-elemene.The pharmacokinetic experiments show that after the S-SMEDDS ofβ-elemene,the relative bioavailability of S-SMEDDS was 152.6%, and it has been much greatly improved in Plasma concentration(Cmax: 6.946±0.33,μg/ml), Time to peak(Tmax: 86.56±1.3, min) and AUC compared with the market Emulsion ofβ-elemene, which providing an experimental basis for the development of oral agents ofβ-elemene.