Research About The Change Of Wnt5a Contained In Hypertrophic Scar

Objective: To observe the content change of wnt5a of Hypertrophic scar.Methods: Choose 12 Clinical Hypertrophic scar patients, which was between 18 and 45, average age was 33, Samples: Taken by operation of 6 normal skin tissue, 6 mature Hypertrophic scar and 6 proliferative stage Hypertrophic scar. To Observe Haematoxylin-Eosin pigmentation of pathology slice and grade it; immunohistochemistry slice positive area rate, to observe the relation of Hypertrophic scar and wnt5a content.Results: 1 Hypertrophic scar have many inflammatory cells2 In whatever dermis light layer or dermis deep layer, the wnt5a positive cell area of proliferative stage Hypertrophic scar or Hypertrophic scar are obviously increase than mature Hypertrophic scar, and proliferative stage Hypertrophic scar wnt5a positive cell area are obviously lager than Hypertrophic scarConclusion : 1. Wnt5a content and proliferative active of Hypertrophic scar are positive pertinence.2. To infer that wnt5a participate establishment of Hypertrophic scar through inflammation as mediate to reaction and accelerated mechanocyte's proliferation and stop apoptosis.