| Fuyanle Capsule(FYLC) contains Phellodendron amurense,kuhseng, dandelion,etc,which has the effect of clearing fever,disintoxicating,dispelling dampness,and stopping leucorrhea.It is mainly used to treat colpitis mycotica and bacterial vaginitis,etc.Objective:To provid some experimental evidence for clinical practice that some pharmacological experimental study of the capsule were done,including the effect on colpitis mycotica mice,and bacterial vaginitis mice,the effect on inflammatory,itching and fever.Methods:The murine model of vaginitis infected with blastomyces albicans or bacteria were established,to observe the therapeutic effects of FYLC on vaginosis mouse.A mouse model of ear swelling induced by xylene smearing and a rat model of hind paw swelling caused by hypodermic injection of carrageenan were used to study the anti-inflammatory effects of FYLC.A mouse model of pantosomatous pruritus induced by intravenous injection of dextran and a cavia cobaya model of topical pruritus caused by histamine phosphate were used to observe the relieving itching effects of FYLC.A rabbit model of fervescence induced bacterial endotoxin was used to study the relieving fever effects of FYLC.Results:It is showed that the FYLC can raise the causative agents darkening rate of bacterial vaginitis mice and Candida albicans vaginitis mice(P<0.05).it also had the evident effect on curing bacterial vaginitis mice' mucosa organism of vagina(P<0.05),inhibited the mice pinna swelling caused by xylene(P<0.05) and rat toes swelling after injecting carrageenan(P<0.05),decreased the frequency of itching in pantosomatous pruritus mice caused by dextran(P<0.05),prolonged the eclipse period of topical pruritus cavia cobaya caused by histamine phosphate (P<0.05),decreased the peak of fervescence rabbits caused by bacterial endotoxin(P<0.05)Conclusion:FYLC was showed to have an obvious effect of healing or improve the symptoms of colpitis mycotica and bacterial vaginitis,it also has the effect of anti-inflammatory,alleviating itching and relieving fever. |
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