Changes And Significance On The Contents Of CCK Acceptors And NOS In Sphincter Of Oddi And On The Contents Of CCK And NO In The Blood Of Cholelitiasis

Objective: To investigate the changes and significance on the contents of CCK acceptors and NOS in sphincter of Oddi and on the contents of CCK and NO in the blood of cholelitiasisMethods: The contents of CCK acceptors and NOS in sphincter of Oddi and the contents of CCK and NO in the blood were determined in 41 patients with gallstone and 12 control.Results: 1.The contents of CCK in the blood of the patients with gallstone were significantly higher than that in the control ,it were38.91±4.85 pmol/L and 30.67±1.81pmol/L respectivel.2. The contents of NO in the blood of the patients with gallstone were significantly higher than that in the control ,it were40.84±4.74pmol/L and32.81±1.11pmol/L respectivel.3.The contents of CCK acceptors in Sphincter of Oddi in the patients with gallstone were significantly lower than that in the control, it were 67.59±5.87pg/Ml and 78.99±1.71pg/mL.4. The contents of NOS in Sphincter of Oddi in the patients with gallstone were significantly lower than that in the control, it were457.52±45.4pg/mL and 519.61±11.38pg/mL.5. Contents of CCK in the blood in the patients with Primary intrahepatic stones, Secondary hepatolithiasis and Choledocholithiasis were 35.21±2.03 pmol/L,40.54±3.59pmol/L and 46.21±1.45 pmol/L; Contents of NO in the blood in the patients with Primary intrahepatic stones, Secondary hepatolithiasis and Choledocholithiasis were 37.41±1.56 pmol/L,41.64±2.57 pmol/L and 49.05±2.91 pmol/L. The contents of CCK and NO in the blood in the different groups with calculus of bile duct were significant higher than those in control.6. Contents of CCK acceptors in the Sphincter of Oddi in the patients with Primary intrahepatic stones, Secondary hepatolithiasis and Choledocholithiasis were 69.90±3.66pg/mL,68.63±5.26pg/mL,58.81±4.34 pg/mL; Contents of NOS in the Sphincter of Oddi in the patients with Primary intrahepatic stones, Secondary hepatolithiasis and Choledocholithiasis were 88.57±14.99pg/mL,454.61±24.70 pg/mL,374.60±25.81 pg/Ml. The contents of CCK acceptors and NOS in the blood in the different groups with calculus of bile duct were significant lower than those in control.Conclusion: 1.There are CCK acceptors and NOS in the Sphincter of Oddi,and the acceptors have activity. The decrease of the contents of CCK acceptors and NOS in Sphincter of Oddi induce cholestatis, which accelerate the formation of gallstone.2. The decrease of the activity and contents of CCK acceptors and NOS in Sphincter of Oddi are in all groups with calculus of bile duct and with cause the breakdown of the Sphincter of Oddi function. The degree of the decrease of the activity and contents of CCK acceptors and NOS in Sphincter of Odd were diferenet .It were the most higher in the group with primary common duct stonesand and .It were higher in the group with cholecystolithiasis and common duct stones than that in the group with primary calculus of intrahepatic duct.3.The contents of CCK acceptors and NOS in Sphincter of Oddi is a important facter which determined its function.4..It is a inverse correlation between increase contents of CCK and NO in the blood and the decrease of the activity contents of CCK acceptors and NOS in Sphincter of Oddi in the patients calculus of bile duct.5. Oddi sphincter in patients with bile duct stones mucosal CCK-AR levels and NOS level of no significant correlation, suggesting that CCK and NO in bile duct stone into the process are possible through various channels play a role.