| Objective To investigate the expression of B7-H1 and CA9 and their relationship in human bladder transitional cell carcinomaMethods The expression of B7-H1 and CA9 in the 50 samples was detected by streptavidin-peroxidase immunohistochemical method, the expression of positive cells for B7-H1 and CA9 was evaluated, and their association with tumor classification, clinical grade, and recurrence were assessed.Results In normal bladder tissue ,B7-H1 and CA9 are not detected. In 43 cases of bladder transitional cell carcinoma , the positive rates of B7-H1 and CA9 expression were 65.11% and 67.44% respectively (P<0.05) .B7-H1 has increased expressions in low grade group(G1-G2) and high grade group(G3), 56.25% and 90.91% respectively (P<0.05) .And the same was to superficial group(T1) and invasive group(T2-T4), 33.33% and 67.57% respectively (P<0.05 ) . In primary group the positive rate of B7-H1 expression was 51.72%,in recurrence group was 92.86% (P<0.05) .CA9 has decreased expressions in low grade group(G1-G2) and high grade group(G3), 78.13% and 36.36% respectively (P<0.05) .And the same was to superficial group(T1) and invasive group(T2-T4), 100% and 54.05% respectively (P<0.05 ) . In primary group the positive rate of CA9 expression was 82.14%, in recurrence group was 40% (P<0.05) .Expression of B7-H1 was correlated with expression of CA9 in bladder transitional cell carcinoma.Conclusions The expression of B7-H1 is strongly associated with neoplastic progression which suggests immune escape may play an important role in bladder transitional cell carcinoma.The expression of CA9 is strongly associated with neoplastic progression which suggests anoxic microenvironment may play an important role in bladder transitional cell carcinoma.B7-H1 and CA9 may play an synergetic role in bladder transitional cell carcinoma, which suggests that neoplastic hypoxic microenvironment due to CA9 may augment expression and adhesive attraction of B7-H1 so as to promote the invasion of tumor.
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