Discussion On The Laser Treatment For Mild/Moderate Nonproliferative Diabetic Retinopathy With Macular Edema

Partâ… Correlation Between Microaneurysms and Diabetic Macular EdemaPurpose:Discussion on the relationship between microaneurysm and diabetic macular edema.Methods:Macular retinal thickness analysis was performed with a Optical Coherence Tomogaphy(OCT) for 30 eyes of 25 diabetic patients. micro-aneurysms were counted in the corresponding macular region by fundusfluoresceinangiography(FFA).And then analyze the relationship between microaneurysm and the total macular volume.Results:There was no correlation between in either total microaneurysms or apparent leaking microaneurysms and the total macular volume(P=0.915 or 0.431,respectively).Conclusion:The number of microaneurysms is not cause diabetic macular edema. Partâ…¡Comparison of Modified-ETDRS and Mild Macular Grid Laser Photocoagulation Strategies for mild /moderate NPDR with Macular EdemaPurpose Comparison the clinical efficacy of Modified-ETDRS and Mild Macular Grid Laser photocoagulation in the treatment of Diabetic Macular Edema.Methods 42 patients of mild/moderate Nonproliferative Diabetic Retinopathy with previously untreated Macular Edema were randomly assigned to receive laser photocoagulation by mETDRS(N=22 eyes) or MMG(N=20 eyes)technique,fundus photographs,optical coherence tomography(OCT) and Visual acuity,Visual field test,Multifocal ERG measurements were obtained at baseline and after 3and 6months.Results(1)OCT show:After 6 months,The decreased thickness of retinal nerve fiber layer(RNFL) of the macular fove and the decreased of the total macular volume(9 region) in the mETDRS group is more than in the MMG group.There is statistical significance of these differences.(2) FFA show:microaneurysms are basically regression in the two groups macular area,There was no statistical significance of the macular leakage between the two groups.(3)After 6 months,There was no statistical significance of the mean change in visual acuity in the mETDRS group and in the MMG group.(4)mfERG show:After 6 months,comparison to pretreatment,the average response densities of N₁-wave and P₁-wave from ring 2 to ring 5 showed significantly lower(P＜0.05),and the average latency of that showed longer(P＜0.05);the average response densities of N₁-wave and P₁-wave at ring 1 showed significantly higher(P＜0.05),and the average latency of that showed shorter(P＜0.05);however,the degree changed of them has no statistical diference between the two groups(P＞0.05).(5)Visual field show:There was no statistical diference in macular light sensitivity at the central 20°in both two groups before treatment between them.The mean light sensitivity at the central 20°showed great difference before and after treatment in both two groups.But the mean reduction of light sensitivity has no statistical diference between them.Conclusions After 6 months treatment,the mETDRS technique is more effective at reducing OCT measured retinal thickening than the MMG laser photocoagulation approach.However,the visual acuity outcome with both approaches is not substantially different.There is no significant diference about the efficiency on macular function between the two groups.