Resting State Functional Magnetic Resonance Imaging Study In Drug-na(?)ve Patients With Obsessive-compulsive Disorder And Control Subjects

Object:Using regional homogeneity (ReHo) technology and amplitude of low-frequency fluctuation (ALFF) technology of the resting functional magnetic resonance imaging (fMRI), we investigate the features of brain activity in patients with obsessive-compulsive disorder. We also try to explore the relationship between the discrete brain activity alterations and obsessive compulsive symptom dimensions.Method:22 obsessive-compulsive disorder patients and 22 well-matched healthy controls were scanned with resting-fMRI. The fMRI data were processed by statistical parametric mapping (SPM8) soft and REST soft based on MATLAB 7.8. We also extract the value of ReHo and ALFF. Two sample t-test was used to detected the brain regions with abnormal ReHo and ALFF. Pearson correlation was used to measure the relationships between mean ReHo values and ALFF values of the clusters and the 4 clinic factorsResults:1. Findings show that the patients had significantly higher ReHo in the left anterior cingulate cortex and significant lower ReHo in the left inferior temporal gyrus compared with healthy controls.2. Compared with healthy controls, we only found significantly higher ALFF in the left anterior cingulate cortex and the left middle cingulate cortex.3. We could not find any correlation between ReHo value and ALFF value in the abnormal brain regions reported above and the 4 clinic factors. There were no significant correlations between obsessive thinking,compulsive behavior and ReHo value and ALFF value in obsessive-compulsive disorder patientsConclusions:1. Our findings provide evidence that the abnormal brain activity of resting state existed even in the drug-naive obsessive-compulsive disorder patients.2. The dysfunction of the left anterior cingulate cortex and the left inferior temporal gyrus might relate to the spontaneous neuronal activity or the intrinsic brain activity of these brain regions.3. The left anterior cingulate cortex and the left inferior temporal were involved in the OCD' pathophysiology and play an important role in the pathophysiology.4. The ReHo and ALFF analytical method were effective for exploring the characteristic of brain activity. The extent of coordination of nervous activity can be reflected by the ReHo analytical method; the strength of neural activity can be reflected by the ALFF analytical method.