Human Leucocyte Antigen-DQA₁ Polymorphism Distribution In Intrahepatic Cholestasis Of Pregnancy

Objective To investigate the relationship between human leucocyte antigen -DQA₁ Polymorphism distribution in intrahepatic cholestasis of pregnancy in zun yi district.Methods The HLA-DQA₁ typing were analysed in blood samples using polymerase chain reaction with sequence-specific primer(PCR-SSP)in twenty patients and ten healthy pregnant women.Results Eleven types of HLA-DQA₁ alleles were detected. Frequency of HLA-DQA₁ * 0302 in ICP is more than healthy pregancy(34.21%,15.79 %),but the analysis showed no statistically significant difference between the two groups (P＞0.05).Conclusion It is unlikely that an HLA-DQA₁ allele is primarily associated with susceptibility or resistance to ICP in Zunyi district.