Analysis On The Independent Association With Atherosclerosis At Different Location

ObjectiveTo investigate the correlation between arteries of different site in the process of atherosclerosis, evaluate whether different risk factors affect different arteries differently.Methods141 hospitalized patients (age 50-80 years) were chosen and coronary angiography or 16-detector spiral CT was performed while giving color doppler ultrasonography check on carotid,lower extremity arteries..According to the results of imaging,all patients were classified into four groups: lower extremity artery disease group (LEAD group),simple coronary atherosclerotic heart disease group (CHD group), healthy group, combined lower extremity artery disease and coronary atherosclerotic heart disease group (LEAD+CHD group). The sex, the age, the dosage and time of smoking and the special medical record such as hypertension, diabetes and intermittent claudication of the patients were collected and the level of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, glycosylated hemoglobin and fibrinogen of them were examined by laboratory.Contrast the atherosclerotic pathology of four groups, and do analysis of variance,chi-square test,analysis of logistic regression, to investigate the difference during the four groups affected by the common risk factors, and evaluate whether the occurrence of atherosclerosis in carotid artery differ from lower extremity arteries. p <0.05 as statistically significant difference.Results1.The comparison of risk factors between the healthy group and the diseased groups: statistical significances of the history of hypertension were inferred at P <0.05 between all the diseased groups and the healthy group. statistical significances of the level of fibrinogen were inferred at P<0.05 between LEAD group and the healthy group, statistical significances of the level of fibrinogen were inferred at P <0.05 between CHD group and the healthy group.The age of LEAD+CHD group was significant higher than the healthy group(P <0.05).The patients with history of smoking in LEAD+CHD group and LEAD group were more than that in healthy group(P <0.05).2.The comparison of risk factors among the diseased groups: The patients with history of smoking in LEAD group were more than that in CHD group(74.28% vs 51.28%,P <0.05). The patients with history of smoking in LEAD+CHD group were more than that in CHD group(75.00% vs 51.28%,P<0.05).3.With the number of atherosclerotic coronary arteries increasing,the rates of the patients with plaques of carotid arteries and lower extremity arteries increase;the rates of the patients with normal of carotid and lower extremity arteries decrease.4.Among all subjects, carotid artery affection accounted for 90.8%, of which only 3.1% express as the formation of stenosis and 89.1% express as the formation of carotid artery plaques;And lower extremity arterial affection accounted for 88.6%, 76.8% of which have entered the period of stenosis formation.Conclusion1.Among risk factors which leading to atherosclerosis, smoking play a greater role in lower extremity arterial disease than that in coronary atherosclerotic heart disase.2.Atherosclerotic trends of carotid arteries,lower extremity arteries,coronary arteries are same;the pathological changes in carotid arteries may appear before that in lower extremity arteries,carotid artery detection might be more useful for early assessment of atherosclerosis.