Effects Of Different Types Of Antiemetics Combined With Dexamethasone On Postoperative Nausea And Vomiting After Supratentorial Craniotomy

Objective To study the effects of different types of antiemetics combined with dexamethasone on postoperative nausea and vomiting after supratentorial craniotomy.Method 200 Patients, ASA scoreⅠ～Ⅱ, scheduled for elective craniotomy were randomly allocated into five groups:Normal saline study group (group P), group Ondanstron 4mg+dexamethasone 10mg (group A), group Metoclopramide 10mg+Dexamethasone 10mg (group B), group Haloperidol 2.5mg+Dexamethasone 10mg (group C),and group Dexamethasone 10mg(group D). Incidences of PONV, severe emetic episodes, requirement of rescue antiemetics and side effets were recorded at postoperative 2 h,6 h, and 24 h, respectively.Results The numbers of patients with PONV, severe emetic episodes,in these four groups of drugs were respectively lower than the group Normal saline, except group dexamethasone, P<0.05. Comparison at all times, PONV incidence, severity emetic episodes and the occurrence of side effects in group A were lower than the other four groups, but it was statistically insignificant between the Group B and Group C (P>0.05); B group of nausea alone was higher than other drug groups (P<0.05); within 24 hours after surgery of group C extrapyramidal symptoms occurred in 2 patients, while there was no significant difference between the other groups (P>0.05).Conclusion Ondansetron, Metoclopramid and Droperidol combined with dexamethasone can safely and effectively reduce the incidence of PONV in patients undergoing neurosurgery.