Ondansetron Administration At Different Timing And Different Doses In Preventing Postoperative Nausea And Vomiting After Gynecologic Laparoscopy

Objective To observe the efficacy of ondansetron of different doses and different timing in preventing of postoperative nausea and vomiting(PONV)after gynecologic laparoscopy,search for an ideal timing and the appropriate dose to prevent and reduce postoperative nausea and vomiting.Methods 80 women between 19 and 44 years of age who were scheduled for elective gynecological laparoscopy under general anesthesia. The ASA grade of all patients wereⅠ～Ⅱ.The patients were divided randomly into 4 groups,20 patients in a group:group A received ondansetron 8mg at 5 minutes before induction of anesthesia;group B received ondansetron 8mg at the end of surgery;group C received ondansetron 4mg at 5 minutes before induction of anesthesia;and group D was not given any antiemetic drug (the control group).The frequency of PONV within the first 24 hours after surgery was evaluated.Results The difference in patients'age,weight,fentanyl doses, anesthesia time,pneumoperitoneum time,infusion volume and underlying diseases was of no statistical significance in four groups.The incidence rate of PONV of group A,B or C was significantly lower than group D(P<0.05);the incidence of PONV of group A and group B showed no significant difference (P>0.05);the incidence of PONV of group A and group C showed no significant difference (P>0.05).The MAP and HR of patients who received ondansetron showed no significant difference.Conclusion Intravenous administration of ondansetron either before induction of anesthesia or at the end of surgery is significantly superior to placebo for PONV prophylaxis after gynecologic laparoscopy.The administration timing have no obvious influence in preventing the occurrence of PONV.Ondansetron 4 mg was chosen as the safe,effective and appropriate dose.