Research Of Relationship Between "Similarity Of The Phenomenon Of Alcohol Withdrawal" And Benign Symmetric Lipomatosis

BackgroundBenign symmetric lipomatosis is a rare benign head and neck disease, the cause of the disease has not yet entirely clear, but it sure is a lot of alcohol-related disease and long-term. Patients with benign symmetric lipomatosis major surgical procedure to restore function through the barrier and the purpose of cosmetic plastic surgery, but the heavier the disease complications, in addition to significant swelling of the neck affect the respiratory airway pressure, the part of patients with inhalation general anesthesia after a clear spirit of clear symptoms, such as facial flushing, delirium, agitation, excitement, then more, questioned answered wrong, no purpose grip, dilated pupils, bilateral upper limb tremor, high blood pressure and sinus tachycardia too fast and so easy to complicated heart, brain dysfunction, patients with life-threatening, high mortality rate. Therefore, the discussion and study of benign symmetrical lipomatosis of psychiatric symptoms in patients with postoperative causes and pathogenesis, greatly reduce the mortality rate after the disease of benign symmetric lipomatosis clinical treatment of postoperative complications and Early prevention is of great significance. In this paper, we first proposed a new concept "category alcohol withdrawal phenomenon", as benign symmetric lipomatosis treated with inhalation general anesthesia and postoperative long-term psychiatric symptoms in patients with a large number of sudden withdrawal of alcohol alcohol after alcohol withdrawal syndrome are very similar, we have called this the "class of alcohol withdrawal phenomenon." "Class of alcohol withdrawal phenomenon" described in the literature at home and abroad are first reported, we adopted the case of this rare and "Class of the phenomenon of alcohol withdrawal," the first, not only for clinical work and research play at home and abroad far-reaching impact, and development of the medical industry has made tremendous contributions.Benign symmetric lipomatosis almost all the main features of the large number of cases have a long history of heavy drinking, the patient suddenly stop drinking or after admission compared with 3-4 days after a significant reduction of alcoholic beverages, some patients alcohol withdrawal syndrome, However, some patients did not occur after drinking alcohol withdrawal syndrome, but the line after enflurane anesthesia noticeable symptoms of sympathetic nerve activity, and clinical symptoms after alcohol withdrawal is very similar to what we call "class alcohol withdrawal phenomenon ", and through clinical observation and access to a large number of documents we found, other surgical departments of the patients with inhalation general anesthesia regained consciousness, some patients also experienced symptoms of sympathetic activity, through the case history showed that most patients have long-term preoperative a lot of history of alcohol abuse. Therefore, we speculated that patients with benign symmetric lipomatosis incentive postoperative psychiatric symptoms may be associated with a large number of preoperative long-term alcohol-related, and further speculated that large quantities of alcohol to all patients combined with inhalation general anesthesia may be a "class quit alcohol off phenomenon. " However, large quantities of alcohol abstinence ten days in patients without any symptoms, row after inhalation general anesthesia a "class of alcohol withdrawal phenomenon" because what is it? Through analysis and study the pathogenesis of alcohol withdrawal syndrome and inhalation general anesthesia after agitation of the reasons, we find that some of the inhalational anesthetics emergence of GABA levels in patients with higher than normal, and alcohol the mechanism of withdrawal syndrome with elevated blood levels of GABA, so we hypothesized that patients with benign symmetric lipomatosis inhalation after general anesthesia "type of alcohol withdrawal phenomenon" may be due to a large number of preoperative long-term alcohol and inhalation general anesthesia in certain inhaled anesthetics, and when fully awake after anesthesia, higher blood levels of GABA, which further induced or wake-occurrence of alcohol withdrawal. In this regard, a lot of alcohol for long-term inhalation anesthesia conscious underwent a "category of alcohol withdrawal phenomenon" causes and pathogenesis will be further confirmed through animal experiments.ObjectiveBenign symmetric lipomatosis of patients after enflurane anesthesia complications "category alcohol withdrawal phenomenon" causes and pathogenesis and clinical significance. Based on the benign symmetric lipomatosis treated with inhalation general anesthesia postoperative "category alcohol withdrawal phenomenon" of research, not only the initial clear benign symmetric lipomatosis treated with inhalation general anesthesia postoperative facial flushing, delirium, agitation, excitement, then more, questioned answered wrong, no purpose grip, dilated pupils, bilateral upper limb tremor, high blood pressure, sinus tachycardia and other sympathetic tone for the symptoms and pathogenesis, but also greatly improve the cure rate of postoperative complications in patients with the disease, clinical work has played an important role in guiding.MethodsSelected 15 healthy male rats do Wistar anesthesia and animal models of alcohol withdrawal, including the control group 5, the alcohol group, 10 rats anesthetized animal model for the 10 ethanol group rats underwent 72 hours of drinking the last inhalation of isoflurane anesthesia. By 52% ethanol (China Luzhou Co., Ltd. to provide), daily from 9:00 am to alcohol fed rats (10ml/kg) a consecutive 4 weeks. Control group received the same dose of normal saline. Were in the alcohol group and the control rats fed the last 4 weeks and drinking alcohol for 30 hours, 72 hours observation of alcohol withdrawal syndrome and to score and 2 ml peripheral venous blood collected in the control group and the anesthesia group received isoflurane anesthesia awake after 15 minutes, 60 minutes and observe the alcohol withdrawal syndrome score and 2 ml peripheral venous blood collected, 3000 rev / min centrifugation for 20 minutes after the serum obtained by using enzyme-linked immunosorbent assay in serumγ-aminobutyric acid ( GABA) concentration. Alcohol withdrawal syndrome score in rats with alcohol dependence and withdrawal behavior signs of audiogenic seizures score standard score.Results1. Alcohol alcohol withdrawal rats 30 hours after the GABA concentration in serum was significantly higher than the control group, 72 hours later returned to normal, similar to the control group; anesthetized rats 15 minutes after anesthesia clear serum GABA concentrations than the control group increased significantly 60 minutes after return to normal, similar to the control group.2. Alcohol alcohol withdrawal rats 30 hours after the withdrawal score was significantly higher, and 72 hours later Back to normal, similar to the control group; anesthesia awake rats 15 minutes after anesthesia was significantly higher withdrawal scores, and 60 minutes later returned to normal, similar to the control group.The results suggest that: alcohol withdrawal and inhaled isoflurane anesthesia regained consciousness, can score and serum withdrawal in rats GABA concentrations were significantly increased, with the difference between the control group were significantly (P <0.05). That is , benign symmetric lipomatosis treated with inhalation general anesthesia complicated by "class alcohol withdrawal phenomenon" because a lot of alcohol and preoperative and long-term inhalation general anesthesia used in some of the inhaled anesthetic drug-related (in this experiment the only confirmed with isoflurane), and the pathogenesis and elevated serum levels of GABA.Conclusion1. Benign symmetric lipomatosis treated with inhalation general anesthesia complicated by "class alcohol withdrawal phenomenon" because a lot of alcohol and preoperative and long-term inhalation general anesthesia used in some of the inhaled anesthetic drug-related (in this experiment with isoflurane, the only confirmed).2. Benign symmetric lipomatosis treated with inhalation general anesthesia complicated by "class alcohol withdrawal phenomenon" in the pathogenesis of postoperative blood with elevated GABA levels. In this study, animal experiments show that: the alcohol group and narcotic withdrawal for 30 hours after the group 15 minutes after anesthesia are awake in the GABA concentration in serum was significantly higher than the control group. Control group with significant difference between the (P <0.05).